University College Cardiff Consultants Limited

Glaxo Wellcome Inc.

Sadie Vile

Alan T Hudson

David Drysdale Miller

Patrick Vivian Shannon

Laddawan Chunchatprasert

Paul Barraclough

Ann Louise Walker

George Stuart Cockerill

Stephen Barry Guntrip

Kathryn Jane Smith

Karl Witold Franzmann

Martin John Page

Stephen Carl McKeown

Pierre P Debont

Substituted heteroaromatic compounds of formula (A) wherein X is N or CH; in which (a) represents a fused 5, 6 or 7-membered heterocyclic ring and R,is a group ZR,wherein Z is joined to R,through a (CH,)p group in which p is 0, 1, or 2 and Z represents a group V(CH,), V(CF,), (CH,)V, (CF,)V, V(CRR&prime;), V(CHR) or V where R and R&prime; are each C,alkyl and in which V is a hydrocarbyl group containing 0, 1 or 2 carbon atoms, carbonyl, dicarbonyl, CH(OH), CH(CN), sulphonamide, amide, O, S(O),or NR,where R,is hydrogen or R,is C,alkyl; and R,is an optionally substituted C,cycloalkyl or an optionally substituted 5, 6, 7, 8, 9 or 10-membered carbocyclic or heterocyclic moiety; or R,is a group ZR,in which Z is NR,, and NR,and R,together form an optionally substituted 5, 6, 7, 8, 9 or 10-membered carbocyclic or heterocyclic moiety, are protein tyrosine kinase inhibitors. The compounds are described, as are methods for their preparation, pharmaceutical compositions including such compounds and their use in medicine, for example in the treatment of psoriasis, fibrosis, atherosclerosis, restenosis, auto-immune disease, allergy, asthma, transplantation rejection, inflammation, thrombosis, nervous system diseases, and cancer.

Bicyclic heteroaromatic compounds as protein tyrosine kinase inhibitors

The present invention relates to heterocyclic compounds which have been found to have anti-tumour activity. More specifically, the invention concerns pyrrolo[2,3-b]carbazoles and 1H-[1] benzothieno [2,3-f] indoles, methods for their preparation, pharmaceutical formulations containing them and their use as anti-tumour agents. The compounds have low toxicity against normal cell lines whilst exhibiting anti-tumour cell activity.

Antitumor tetracyclic compounds

Pyrrolo�3,2-b-!-carbazoles and 1H�1!benzothieno �2,3-f! indoles having

Heterocyclic compounds

Growing community of inventors

Stevenage, United Kingdom

Sadie Vile