Osaka University

National Institute of Infectious Diseases

Toko Yakuhin Kogyo Kabushiki Kaisha

The Research Foundation for Microbial Diseases

Sadao Manabe

Iwao Yoshida

Konosuke Fukai

Hiroyuki Fujita

Akihisa Takamizawa

Juichiro Osame

Keisuke Takaku

Mitsuo Takagi

Hideki Hasegawa

Takashi Miyazaki

Taizou Kamishita

Chisato Mori

Takeo Konobe

Takeshi Tanimoto

Masahiko Kato

Toyokazu Ishikawa

The present invention provides a vaccine composition for transnasal mucous membrane administration, which contains an influenza virus antigen, polyriboinosinic polyribocytidylic acid (poly (I:C)) or a derivative thereof and a carboxyvinyl polymer. The present invention also provides a prophylactic method of influenza, including a step of administering the vaccine composition at least once to the nasal mucosa of a subject in need thereof.

Method for prophylaxis of influenza using vaccine for intranasal administration

There is disclosed an antigen comprising an amino acid sequence of the suce antigen of a hepatitis B virus. The present antigen can be produced easily and safely at low cost by means of recombinant DNA technique. The present antigen can be used as an effective vaccine and diagnostic for hepatitis B.

Process for expressing the hepatitis B virus antigen using a

There is provided a recombinant Marek's disease virus comprising the genomic DNA of an attenuated Marek's disease virus and a foreign gene from another source. The present recombinant virus can advantageously be used as an active ingredient for a multifunctional live vaccine, exhibiting not only the antigenicity and immunogenicity of the Marek's disease virus but also the properties ascribed to the foreign gene. Since the suitable host cell for the recombinant virus of the present invention is an avian cell which is available in a large quantity and not expensive, the recombinant virus of the present invention can be produced efficiently at low cost on a commercial scale.

Recombinant Marek's disease virus and vaccine

There is disclosed a DNA which codes for an antigen comprising at least part of an amino acid sequence of the antigen of a flavivirus, which part contains at least one epitope of the flavivirus antigen. The present DNA can be used for producing the antigen easily and safely at low cost by means of recombinant DNA technique. The antigen produced using the present DNA can be used as an effective vaccine and diagnostic for Japanese encephalitis.

A DNA coding for a Flavivirus antigen

There is disclosed an antigen comprising at least part of an amino acid sence of the antigen of a flavivirus, which part contains at least one of epitopes of the flavivirus antigen. The present antigen can be produced easily and safely at low cost by means of recombinant DNA technique. The present antigen can be used as an effective vaccine and diagnostic for Japanese encephalitis.

Flavivirus antigen

Growing community of inventors

Mitoyo-gun, Japan

Sadao Manabe