Katayama Seiyakusyo Co., Ltd.

Ajinomoto Co., Ltd.

Sadao Hayashi

Yasuyuki Kurita

Eiji Nakanishi

Masahiko Okunishi

Novel cephalosporin derivatives of formula (II): ##STR1## wherein R.sup.2 is hydrogen, methyl, or fluoromethyl; R.sup.3 is hydrogen, methyl or carboxyl; R.sup.4 is hydrogen or methyl; A is methylene or propenylene; Q is nitrogen or CH, and pharmaceutically acceptable salts, solvates, hydrates and esters thereof, a process for their preparation and an antimicrobial composition containing them.

Cephem compounds, their preparation and their use as antimicrobial agents

Herein disclosed are novel cephem compounds represented by the following general formula (I), and novel antimicrobial, and especially anti-MRSA, agents which contain as an active ingredient at least one of the novel cephem compounds and the physiologically acceptable salts thereof. ##STR1##

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Hirakata, Japan

Sadao Hayashi