Taiho Pharmaceutical Company Limited

Taisho Pharmaceutical Co., Ltd.

Sadao Hashimoto

Setsuro Fujii

Kazuo Ogawa

Yoshiyuki Muranaka

Toshihiro Hamakawa

Norio Unemi

Kenji Kitazato

Mitugi Yasumoto

Junichi Yamashita

Ichiro Yamawaki

Katsuo Takikawa

Takashi Suzue

Yoko Osame

Hiroshi Minami

Ryuji Sakakibara

Yasushi Kurashige

Novel sulfonate derivatives represented by the formula

Antilipemic and anti-inflammatory compositions containing sulfonate

A sulfonate derivative represented by the formula ##STR1## wherein R.sub.1 is lower alkyl, lower alkoxy or halogen, l is an integer of from 0 to 3, n is 0 or 1, A is straight-chain or branched-chain alkylene having 1 to 4 carbon atoms, and R.sub.2 is hydrogen or lower alkyl but, when n is 0 or 1 and A is straight-chain alkylene with 1 to 4 carbon atoms, is not hydrogen and the method for preparing the same.

Sulfonate derivatives, process for preparing same and antilipemic

Method of treating hyperlipidemia and inflammation with sulfonate

A 5-fluoropyrimidin-4-one derivative represented by the formula ##STR1## wherein R is straight-chain or branched-chain alkyl having 4 to 18 carbon atoms, straight-chain or branched-chain alkenyl having 2 to 18 carbon atoms, alkylene oxido having 3 to 10 carbon atoms, aryl or aralkyl;

Preparation of 5-fluoropyrimidin-4-one derivatives

A 5-fluoropyrimidin-4-one derivative represented by the formula ##STR1## wherein R is straight-chain or branched-chain alkyl having 4 to 18 carbon atoms, straight-chain or branched-chain alkenyl having 2 to 18 carbon atoms, alkylene oxido having 3 to 10 carbon atoms, aryl or aralkyl; Processes for preparing the derivative; An anti-tumor composition containing the derivative as an effective component and an excipient.

5-Fluoropyrimidin-4-one compositions

An N-substituted guanidino acid derivatives having the following formula of ##EQU1## wherein R is an alkyl having 6 to 15 carbon atoms,. a cycloalkyl having 6 to 15 carbon atoms or an aryl(C.sub.6 to C.sub.8)alkyl(C.sub.1 to C.sub.9); A represents R.sup.1 or R.sub.2 CO--, R.sup.1 being an alkyl having 1 to 4 carbon atoms, an alkenyl having 2 to 4 carbon atoms, cyclohexyl, a phenyl containing or not containing a substitute of a lower alkyl, a halogenated lower alkyl, a lower alkoxy, hydroxy or a halogen, or a benzyl containing or not containing a substitute of a lower alkyl, a halogenated lower alkyl, a lower alkoxy, hydroxy or a halogen, and R.sup.2 being an alkyl of 1 to 3 carbon atoms, an alkenyl of 2 to 3 carbon atoms, an aryl of 6 to 8 carbon atoms or an aryl(C.sub.6 to C.sub.8)alkyl(C.sub.1 to C.sub.2); and n is an integer of 4 to 10. The present compounds are excellent in pharmacological activities, particularly in antagonism to bradykinin and histamine, and useful as anti-inflammatory agent.

N-substituted guanidino acid derivatives

Growing community of inventors

Tokushima, Japan

Sadao Hashimoto