Ishihara Sangyo Kaisha, Ltd.

Sadanori Mizukoshi

Nobutoshi Yamada

Kenji Kon

Hideo Sugi

Hajime Murakami

Fuminori Kato

Kenichi Ichimura

Masamitsu Tsukamoto

Taiji Katayama

An immuno-suppressive agent containing, as an effective component, an, enopyranose derivative of the following formula (I) or its salt: ##STR1## wherein R.sup.1 is a hydrogen atom, alkyl which may be substituted, alkenyl, alkynyl, --OSO.sub.2 R.sup.7, a halogen atom, --OCOR.sup.7, --NHCOR.sup.8, alkoxy, phenyl which may be substituted or a saccharose residue, R.sup.2 is a hydrogen atom or alkyl, R.sup.3 is a hydrogen atom or a halogen atom, R.sup.4 is a hydrogen atom, --COR.sup.9, silyl which may be substituted or alkyl which may be substituted, one of R.sup.5 and R.sup.6 is hydroxyl, alkoxy which may be substituted, a saccharose residue, cycloalkyloxy which may be substituted or --OCOR.sup.10 and the other is a hydrogen atom or alkyl which may be substituted, or R.sup.4 and R.sup.5 together form a single bond, while R.sup.6 is a hydrogen atom or alkyl which may be substituted, each of R.sup.7, R.sup.9 and R.sup.10 is alkyl or phenyl which may be substituted, R.sup.8 is alkyl, phenyl which may be substituted or benzyloxy, X is a hydrogen atom, alkyl which may be substituted, alkenyl which may be substituted, alkynyl which may be substituted, cycloalkyl which may be substituted, phenyl which may be substituted, pyridyl which may be substituted, furanyl which may be substituted, thienyl which may be substituted, formyl, --COR.sup.11, --C(W.sup.1)W.sup.2 R.sup.11 or --SO.sub.2 R.sup.11, R.sup.11 is a chain hydrocarbon group which may be substituted, a monocyclic hydrocarbon group which may be substituted, a polycyclic hydrocarbon group which may be substituted, a monocyclic heterocycle group which may be substituted, or a polycyclic heterocycle group which may be substituted, W.sup.1 is an oxygen atom or a sulfur atom, W.sup.2 is an oxygen atom, a sulfur atom or --NH--, Y is a hydrogen atom, alkyl which may be substituted, alkenyl which may be substituted or alkynyl which may be substituted.

Immuno-suppressive agent

Exo-3',4'-O-benzylidene-3'-dimethylchartreusin (exo-BDMC) or its salts and 3'-demethylchartreusin (3'-DMC) or its salts are provided according to the present invention. Exo-BDMC and its salts are useful for antitumorous agents and antibacterial agents. 3'-DMC and its salts are useful as starting materials for producing exo-BDMC.

Exo-3',4'-O-benzylidene-3'-demethylchartreusin and its salts

Antimicrobial powders are obtained by suppporting at least one antimicrobial metal of copper, zinc and alloys thereof on the surface of hydrous titanium oxide or titanium oxide particles by electroless plating, vapor deposition, compression mixing, mixing and reducing, and thermal decomposition of a compound. These powders are used to provide antimicrobial resin compositions, antimicrobial rubber compositions, antimicrobial glass compositions and antimicrobial coating compositions.

Method of making titanium oxide powder having antimicrobial metal

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Kusatsu, Japan

Sadanori Mizukoshi