The UAB Research Foundation (the University of Alabama at Birmingham)

Virtual Drug Development, Inc.

Sadanandan Velu

Lawrence James DeLucas

Wayne J Brouillette

Christie G Brouillette

Donald D Muccio

Laurent Schmitt

Mark J Jedrzejas

Yancho Devedjiev

Jose Gabriel Garcia

Walter Cristofoli

Hui Wu

Yong-Chul Kim

Liyuan Mou

Bhavitavya Nijampatnam

Aimee Morrison

R Stephen Porter

Qiong Zhang

The present invention is related to the inhibition of the formation of Streptococci biofilms through the inhibition of glucosyl transferase (Gtf). Compounds, compositions and methods for inhibitingbiofilm formation, as well as for preventing, inhibiting and/or treating the formation of dental caries, and methods of identifying compounds that prevent, inhibit and/or treat the formation of dental caries are provided.

glucosyl transferase inhibitors for dental caries therapy

The present invention provides methods, compounds, compositions and kits including mitochondrially-targeted electrophilic (MTE) compounds that are useful for treating cancer.

Mitochondrially-targeted electrophilic compounds and methods of use for the treatment of cancer

Disclosed are compounds that inhibit the microbial NAD synthetase enzyme. For example, disclosed are compounds of the formula Ar&#x2014;X&#x2014;Ar&#x2014;Y&#x2014;L&#x2014;Z&#x2014;Q, wherein Q is QAror ArQ; Ar, Ar, and Arare independently aryl or heteroaryl, optionally substituted with one or more substituents; X, Y, and Z are independently selected from the group consisting of a covalent bond or groups containing one or more of C, H, N, O, S atoms; L is a linker and Qis an alkylenyl, alkylenyl carbonyloxy alkyl, or alkylenyl carbonylamino alkyl group, optionally having a substituent; a covalent bond; a group containing amidine or guanidine function wherein the amidine or guanidine may be optionally N-substituted with an alkyl; or a zwitterion; or a pharmaceutically acceptable salt thereof. Also disclosed are methods which involve the use of the compounds of the present invention, for example, in treating or preventing a microbial infection in a mammal or plant, killing a prokaryote or decreasing prokaryotic growth, disinfecting a material or environment contaminated by a microbe, increasing food animal production, controlling harm to plants by a pest or insect, and combating agroterrorism. Examples of microbes affected by the compounds of the present invention are bacteria and fungi.

NAD synthetase inhibitors and uses thereof

The present invention provides methods of synthesizing and screening inhibitors of bacterial NAD synthetase enzyme, compounds thereof, and methods of treating bacterial and microbial infections with inhibitors of bacterial NAD synthetase enzyme.

Inhibitors of bacterial NAD synthetase

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Birmingham, AL, United States of America

Sadanandan Velu