Hitachi-high-technologies Corporation

Hitachi High-tech Corporation

Sadamitsu Aso

Kenko Uchida

Toshinari Sakurai

Hideharu Hattori

Yasuki Kakishita

Kazumichi Imai

Eiichiro Takada

Akihiro Shimase

Masako Kawarai

Mitsugu Sato

Takashi Ohshima

Taku Sakazume

Yusuke Ominami

Sukehiro Ito

Hideo Morishita

Satoshi Mitsuyama

Chihiro Manri

Norio Owada

Fumiaki Hamazato

A machine learning device with a processor and a memory, in which the processor receives an image and calculates a feature amount of an object included in the image, the processor identifies a local part from the feature amount and calculates a local identification value, the processor calculates an overall identification value using the local identification value, and the processor generates a classifier using the local identification value and the overall identification value and stores it in the memory.

Machine learning device, image diagnosis support device, machine learning method and image diagnosis support method

An image diagnosis assisting apparatus according to the present invention executes: processing of inputting an image of a tissue or cell; processing of extracting a feature amount of a tissue or cell from a processing target image; processing of extracting a feature amount of a tissue or cell from an image having a component different from that of the target image; and processing of determining presence or absence of a lesion and lesion probability for each of the target images by using a plurality of the feature amounts.

Image diagnosis assisting apparatus, image diagnosis assisting system and image diagnosis assisting method

Reaction values indicating based on which areas in an input image a plurality of identification results representing the states of cells or tissues are judged are calculated, and differences between a plurality of reaction values are obtained to thereby calculate the degree to which cells or tissues in an area of interest likely are in each state. Thereby, each state of cells or tissues can be visualized at an accurate position in an area of interest; therefore, diagnostic assistance to pathologist becomes possible.

Image diagnosis assisting apparatus, image diagnosis assisting method and sample analyzing system

A diagnostic imaging assistance apparatus according to the present invention performs a process of inputting images of a tissue and a cell, a process of extracting feature amounts of a wide view and a narrow view from a target image to be processed, a process of classifying whether the target images having different views are normal or abnormal from the feature amounts, and a process of classifying a lesion likelihood using a classification result.

Diagnostic imaging assistance apparatus and system, and diagnostic imaging assistance method

The present invention addresses the problem of providing: a cell dispersion measurement mechanism whereby it becomes possible to fully disperse cells regardless of the experiences of operators skilled in cell culture and it also becomes possible to determine the number or concentration of cells accurately; a cell culture apparatus equipped with the cell dispersion measurement mechanism; and a cell dispersion measurement method. The problem can be solved by circulating a cell suspension in a flow path to disperse cell masses contained in the cell suspension, and then determining over time the number or concentration of cells and/or the degree of dispersion of cells in the cell suspension that is flowing in the circulation flow path.

Cell dispersion measurement mechanism, and cell subculture system utilizing same

The present invention realizes determination of tissues and cells from an image by calculating feature values of a deformed degree of the cells even in a case where the tissues or the cells have various shapes. An image diagnosis support apparatus according to the present invention executes processing of inputting an image of cells, processing of extracting the feature values of a plurality of direction components from a target image of the processing, processing of determining whether or not the image corresponds to one-classification by using the plurality of feature values, and processing of determining whether or not the determination processing is finished with respect to all of the classifications set in advance (FIG.).

Cytologic diagnosis support apparatus, cytologic diagnosis support method, remote diagnosis support system, service providing system, and image processing method

According to the present invention, a simple structure can be used to achieve reliable liquid delivery with no residual air, and simple attachment/detachment of a culture vessel, and thus a closed-system cell culture device exhibiting high reliability can be constructed at low cost. In the present invention, a liquid is supplied or discharged while a culture vessel is in an inclined state. The culture vessel is provided with two flow paths, namely an intake flow path and a discharge flow path, which connect a culture chamber and a connection member. Points where the flow paths join with the culture chamber are respectively configured as an intake port and a discharge port. The discharge port is provided in the position nearest to the axis of inclination of the culture vessel. The intake port is provided in a plane projected from a vertical plane including the aforementioned axis of inclination.

Cell culture device

The purpose of the present invention is to eliminate the effort in placement and extraction of samples in observations using transmitted charged particles. A charged particle beam device () is characterized by having: a charged particle optical lens tube that irradiates a sample () with a primary charged particle beam; a sample stage on which a light emitting member () that emits light because of charged particles that have come by transmission internally in the sample () or scattering therefrom or a sample platform () having the light emitting member () is attachably and detachably disposed; and a detector () that detects the light emitted by the light emitting member.

Charged particle beam device, sample observation method, sample platform, observation system, and light emitting member

According to the present invention, a problem of closed systems, namely minimizing the number of electromagnetic valves required to control a plurality of flow paths, can be addressed, and thus a low-cost cell culture device can be achieved. In this flow-path control method for X number of flow paths satisfying X&#x2264;2, the X number of flow paths are selected by using N number of valves to simultaneously and selectively control the opening and closing of the plurality of flow paths.

Flow-path control method, and cell culture device

A device which automatically performs a step in which expanded and cultured cells are diluted to a desired cell concentration and re-inoculated using a cell-concentration adjustment device having an inlet for taking in a cell suspension; an outlet for discharging a diluted cell suspension; and a flow path which is provided between the inlet and the outlet and is capable of holding a cell suspension, the flow path being provided with: a liquid delivery pump for causing a cell suspension inside to flow; a cell-concentration measurement instrument for collecting data related to a cell concentration per unit amount of the cell suspension; and a dilution-liquid container for holding a dilution liquid which is supplied to the flow path to dilute the cell suspension. The device further includes a control unit for controlling at least the liquid delivery pump on the basis of the data obtained by the cell-concentration measurement instrument, wherein the control unit determines, on the basis of the data obtained by the cell-concentration measurement instrument, an amount of the dilution liquid required to bring the cell concentration to the desired concentration, and drives the liquid delivery pump so as to take in the required amount of the dilution liquid into the flow path and mix the cell suspension and the dilution liquid.

Cell concentration adjustment device, and automatic subculture system using same

Disclosed is a flow cytometer using a spectral device and a multi-detector, in which setting of an optimum wavelength band prior to measuring fluorescence intensity in real time is supported. A signal processing unit stores the intensities in multiple wavelength bands, the intensities being obtained by measuring a calibration sample, and the distribution of the intensities is calculated and displayed by each of the wavelength bands.

Growing community of inventors

Tokyo, Japan

Sadamitsu Aso