National Cerebral and Cardiovascular Center

Osaka University

Jms Co., Ltd.

Tokyo University of Science Education Foundation Administrative Organization

Sachiro Kakinoki

Tetsuji Yamaoka

Atsushi Yamashita

Satoshi Obika

Tsuyoshi Yamamoto

Takeshi Imanishi

Mariko Shiba

Yoshiya Hashimoto

Yoichi Tachibana

Kiyomi Sasaki

Satoshi Kato

Keisuke Narukawa

Atsushi Kasai

Shunsuke Baba

Hidetaka Torigoe

A peptide that enables surface treatment of a scaffold for tissue repair that makes it possible to accelerate the repair of living tissue without using a material that negatively affects the repair of living tissue, a complex containing this peptide, a scaffold for tissue repair surface treated using this peptide or this complex, a surface treatment method for a scaffold for tissue repair using this peptide or this complex, and a treatment solution or set of treatment solutions to be used in this surface treatment method. Surface treatment of a scaffold for tissue repair is conducted by combining glycosaminoglycan and a peptide containing adhesive sites and basic sites each comprising predetermined amino acid residues.

Peptide and complex of same, scaffold for tissue repair and surface treatment method for same, and surface treatment solution or set of treatment solutions

An object of the present invention is to provide an oligonucleotide useful as a therapeutic agent for dyslipidemia that has excellent binding affinity to the PCSK9 gene as well as stability and safety. The oligonucleotide of the present invention contains a sugar-modified nucleoside, the sugar-modified nucleoside has a bridging structure between 4'-position and 2&#x2032;-position, and the oligonucleotide can bind to the human PCSK9 gene. Also, the present invention provides a therapeutic agent for dyslipidemia containing the oligonucleotide as an active ingredient, and the therapeutic agent preferably contains a bioabsorbable material as a carrier. The bioabsorbable material is preferably atelocollagen or peptide gel.

Oligonucleotide, and therapeutic agent for dyslipidemia containing oligonucleotide as active ingredient

A blood anticoagulant material is provided which has high expandability, reduced influence on living bodies, and can efficiently prevent blood coagulation. A multiblock copolymer having at least a structural unit represented by Formula (1), a structural unit represented by Formula (2), and a structural unit represented by Formula (3) is used: wherein, R, R, and Rin Formulas (1) to (3) each independently represent a divalent organic group, and m and n each independently represent an integer of 2 to 5000.

Blood anticoagulant material, coating material and indwelling device comprising the same, and treatment using blood anticoagulant material

Growing community of inventors

Osaka, Japan

Sachiro Kakinoki