Maruko Seiyaku Co., Ltd.

Sachio Ohno

Mitsuaki Nagasaka

Kiyoshi Mizukoshi

Osamu Komatsu

Mikio Hori

Hajimu Yamamoto

Yoshiki Nakamura

Kazuo Kato

Hajime Fujimura

Kenji Ichihara

Tadashi Kitamikado

Takao Ban

Kiyoshi Kato

Takashi Morishima

Yuko Ebihara

Kenzi Ichihara

Osamu Ootani

Kihachiro Izumi

Yasuo Kunou

Novel ergoline derivatives and acid addition salts thereof are disclosed. These ergoline derivatives possess excellent anti-hypertensive activity, vasodilating activity, anti-ulcer activity, gastric secretion inhibitory activity, brain metabolism improving activity, anti-depressive activity and dopamine-like activity, and, therefore, are useful for prevention and treatment of various diseases such as hypertension, a wide variety of vein disorders, peptic ulcer, brain absormality, depression, Parkinson's disease, high prolactin blood disease, etc.

Ergoline derivatives and acid addition salts thereof

Novel pyridine compounds and the pharmaceutically acceptable salts thereof having a specific inhibitory activity on thromboxane A.sub.2 biosynthesis in mammals useful for prevention and treatment of various disorders caused by thromboxane A.sub.2, for example, thrombosis, cardiac infarction, diabetic vascular complications, asthma, etc. are disclosed.

Certain pyridyloxy-or-thio-phenyl propenoic acid derivatives

1,4-Dihydropyridine compounds having excellent coronary and vertebral vasodilation, blood pressure depression and anti-hypertensive activities are disclosed. These compounds are low toxic and stable to light, and are very useful for pharmaceutical agents.

1,4-Dihydropyridine compounds

Novel thiopyranopyrimidine compounds and the pharmaceutically acceptable acid addition salts thereof having excellent hypoglycemic activity, platelet aggregation inhibitory activity, antihistamine activity and anti-allergy activity useful for prevention and treatment of various disorders caused by diabetes, allergy and the like are disclosed.

Thiopyranopyrimidine compounds and acid addition salts thereof

A flavan compound represented by the formula (I) ##STR1## wherein R, R.sub.1, R.sub.2 and R.sub.3 are as defined above, and the pharmaceutically acceptable acid addition salt thereof, which are useful as pharmaceutical agent having anti-convulsive, anti-ulcer, anti-arrythmic and diuretic activities.

Flavan compounds and acid addition salts thereof

Cis or trans-1,5-benzothiazepine compounds represented by the formula (I): ##STR1## wherein R.sub.1 represents a hydrogen atom, a halogen atom, an alkyl group or an alkoxy group and R.sub.2 represents a hydrogen atom, an alkyl group or a hydroxyalkyl group and the pharmaceutically acceptable acid addition salts and quaternary ammonium salts thereof which exhibit anticholinergic activity and are useful as anti-ulcer, gastric secretion inhibiting and antispasmodic agents in mammals, and a process for preparing the same.

1,5-Benzothiazepine compounds

Pyrazole derivatives represented by the formula ##SPC1## Wherein R, X, R.sub.2 and R.sub.3 are hereinafter defined, which are useful as analgesics and anti-inflammatory agents and a process for preparing the pyrazole derivatives are disclosed.

Growing community of inventors

Aichi, Japan

Sachio Ohno