Mitsubishi Petrochemical Company Limited

Mitsubishi Chemical Industries Limited

Sanyo Fine Co., Ltd.

Sachio Hirose

Takashi Kurihara

Eiji Taniyama

Masanobu Inagawa

Yoshitaka Sako

Hidenari Adachi

Tammotsu Homma

Motomu Hane

Makiko Shibata

There is disclosed a novel .gamma.-carboxyglutamic acid, a method for preparing the same and a method for preparing Gla.sup.17 human osteocalcin and Glu.sup.17 human osteocalcin or salts of these, which comprises introducing .gamma.-carboxyglutamic acid in a peptide synthetic method of human osteocalcin by use of a protected L-.gamma.-carboxyglutamic acid represented by the formula: ##STR1## wherein n represents 0, 1 or 2, or a salt thereof.

Amino acid derivative, method for preparing the same and method for

Gla.sup.17 human osteocalcin and Glu.sup.17 human osteocalcin or salts thereof are prepared by introducing .gamma.-carboxyglutamic acid into the amino acid sequence of said osteocalcin by employing a protective L-.gamma.-carboxyglutamic acid represented by the formula: ##STR1## wherein n represents 0, 1 or 2, or a salt thereof in the appropriate position in the reacting sequence of amino acids which form the osteocalcin.

Y-carboxyglutamate derivative, method for preparing the same and method

There is disclosed a calcitonin derivative and its salt, comprising an amino acid residue at the 1-position of calcitonin which is a cyclic amino acid residue represented by the formula: ##STR1## wherein X represents a sulfur atom or a methylene group; and n represents an integer of 0 or 1. and an amino acid residue at the 7-position which is a cysteine residue which may be substituted with an appropriate protective group.

Novel calcitonin derivative and salt thereof

There are disclosed a novel polypeptide represented by the formula shown below or its acid addition salt or complex: ##STR1## wherein Ala represents alanine, Ser serine, Leu leucine, Thr threonine, Val valine, Gly glycine, Lys lysine, Gln glutamine, Glu glutamic acid, His histidine, Tyr tyrosine, Pro proline, Arg arginine, Asp aspartic acid, and n represents an integer of 3 to 7, and a process for producing the same comprising forming a peptide or polypeptide represented by the above formula and subjecting the structural units containing a peptide residue represented by the formula: ##STR2## wherein R represents an active ester residue, Ala, Ser, Leu, Thr and n have the same meanings as defined above, formed in any step of the reaction to cyclization reaction.

Novel polypeptide and process for producing the same

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Tokyo, Japan

Sachio Hirose