Glenmark Pharmaceuticals S.a.

Sachin Vasantrao Dhone

Neelima Khairatkar-Joshi

Sachin Sundarlal Chaudhari

Ashok Bhausaheb Kadam

Abraham Thomas

Sukeerthi Kumar

Indranil Mukhopadhyay

Vishal Govindrao Deshmukh

Nisha Parag Patil

Rajendra Prakash Chikhale

Vidya Ganapati Kattige

Suresh Mahadev Kadam

Daisy Manish Shah

Malini Bajpai

Bharat G Adik

Thomas Abraham

Neelima Khairatkar-joshi

The present disclosure is directed to compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein Ring A, Ring B, R, R, R, n, and p are as defined herein, which are active as modulators of retinoid-related orphan receptor gamma t (ROR&#x3b3;t). These compounds prevent, inhibit, or suppress the action of ROR&#x3b3;t and are therefore useful in the treatment of ROR&#x3b3;t mediated diseases, disorders, syndromes or conditions such as, e.g., pain, inflammation, COPD, asthma, rheumatoid arthritis, colitis, multiple sclerosis, psoriasis, neurodegenerative diseases and cancer. 

Aryl and heteroaryl ether compounds as ROR gamma modulators

The invention described herein relates to novel fused pyrimidinediones derivatives of formula (I) which are TRPA (Transient Receptor Potential subfamily A) modulators. In particular, compounds described herein are useful for treating or preventing diseases, conditions and/or disorders modulated by TRPA1 (Transient Receptor Potential subfamily A, member 1). This invention also provides processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders modulated by TRPA1. 

Fused pyrimidine-dione derivatives as TRPA1 modulators

The present invention provides transient receptor potential vanilloid (TRPV) modulators of formula (I). In particular, compounds described herein are useful for treating or preventing diseases, conditions and/or disorders modulated by TRPV3. Also provided herein are processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders modulated by TRPV3. 

Fused imidazole carboxamides as TRPV3 modulators

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Usmanabad, India

Sachin Vasantrao Dhone