Council of Scientific and Industrial Research

Sachin Srivastava

Sunil Kumar Chattopadhyay

Arvind Singh Negi

Suman Preet Singh Khanuja

Ankur Garg

Ranganathan Santha Kumar Tirupadiripuliyur

Sushil Kumar

Asish Kumar Bhattacharya

Koneni Venkata Sashidhara

Vinayak Tripathi

Guru Das Bagchi

Vijay Kumar Mehta

Raghvendra Kumar Mishra

Prem Dutt Dwivedi

Vinayah Tripathi

The present invention provides a process for production of an anticancer taxoid brevifoliol of the formula I from plants belonging to the genusby first extracting the dried and pulverized leaves of the plant with an alcohol preferably at a temperature in the range of 20-40&#xb0; C. and then. concentrating the solvent to obtain an alcoholic extract. The alcoholic extract obtained is then adsorbed with an adsorbent and the resulting adsorbed material is then dried at a temperature ranging from 20-50&#xb0; C. for 4-48 hours. The dried adsorbed material is then extracted with a combination of an aliphatic solvent and a chlorinated solvent successively and concentrated to obtain a residue. The residue is subjected to gross fractionation using column chromatography such as silica gel, florosil and silicic acid followed by chromatography with a suitable adsorbent to get brevifoliol.

Process for preparing brevifoliol

The present invention relates to the bioactivity of taxanes isolated from the leaves of Himalayan Yew treeagainst human cancer cell lines grown in-vitro and subsequent identification of brevifoliol [1] as anticancer agent useful in the treatment of various types of cancer in humans 

Pharmaceutical composition containing brevifoliol for use in chemotherapeutic treatment of human beings, method therefor

Demethylation of 3', 4&#x2032;-dimethoxy or 3&#x2032;, 4&#x2032;, 5&#x2032;-trimethoxy benzoic ester of a phenol is carried out in the presence of an excess of aluminum halide in an organic solvent to get 4&#x2032;-Hydroxy, 3&#x2032;-methoxy or 4&#x2032; hydroxy, 3&#x2032;, 5&#x2032;-dimethoxy benzoic acid ester of a phenol. The reaction is also applicable to 3&#x2032;, 4&#x2032;, 5&#x2032;-trimethoxy diaryl ketone and some natural products like reserpine.

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Process for the production of vasicine

Process for the preparation of 10-deacetylbaccatin III

A process has been developed for production of a food flavoring compound maltol which comprises (a) extracting the dried and pulverized leaves of the plants belonging to the genus Abies with an alcohol at 20-40&deg; C. and concentrating the solvent to obtain an alcoholic extract, (b) adsorbing the alcoholic extract with an adsorbent and drying the adsorbed material at a temperature ranging between 20-50&deg; C., (d) partitioning of the adsorbed material between selected solvents consisting of aliphatic hydrocarbon and chlorinated solvent successively, (d) concentrating the chlorinated solvent to a residue and crystallizing it from a suitable organic solvent or mixtures of such solvents to get pure maltol.

Process for the preparation of maltol from plants belonging to the genus Abies

The present invention relates to a process for the production of (&minus;)3,4-divanillyl tetrahydrofiran of formula (2) which comprises (a) isolating) (&minus;) secoisolariciresinol of formula (1) from the heartwood and roots of by an improved process which consists of partitioning of the alcoholic extract of the heartwood and roots of between water and chlorinated solvent, (b) extracting the chlorinated solvent extract with alkali and (c) isolating (&minus;) secoisolariciresinol from the alkali extract upon neutralization with mineral acid and extracting with organic solvent and (d) crystallizing it from suitable organic solvent, (e) dissolving the isolated (&minus;) secoisolariciresinol in suitable organic solvent and (f) reacting with triphenyl phosphine halide at 0-80&deg; C. for 1-10 hours and (g) isolating (&minus;) 3,4-divanillyl tetrahydrofuran by column chromatography.

Process for the production of (&minus;) 3,4-divanillyl tetrahydrofuran

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Uttar Pradesh, India

Sachin Srivastava