Lupin, Inc.

Sachin Sethi

Venkata Poornapragnacharyulu Palle

Rajender Kumar Kamboj

Milind Dattatraya Sindkhedkar

Prathap Sreedharan Nair

Sanjeev Anant Kulkarni

Anil Kashiram Hajare

Mahadeo Bhaskar Tryambake

Chetan Sanjay Pawar

Chaitanya Prabhakar Kulkarni

Ganesh Bhausaheb Gudade

Dipak Raychand Lagad

Balasaheb Arjun Gore

Manojkumar Ramprasad Shukla

Samiron Phukan

Nilesh Raghunath Khedkar

Pradeep Rangrao Patil

Dagadu Dube

Vikas Sitaram Tambe

Pradip Balu Wagh

Sudhakar Maruti Balgude

Ganesh Kakade

Disclosed are compounds of the general formula (I), its tautomeric form, its stereoisomer, its pharmaceutically acceptable salt, its polymorph, or solvate thereof, Formula (I) wherein, ring A, Rto R, X, Y, m, and n are as defined herein, for use as SOS1 inhibitors in the treatment of proliferative, infectious and RASopathy diseases or disorders. Also disclosed are methods of synthesizing the compound of formula I, pharmaceutical compositions containing the compound of formula I, method of treatment of proliferative, infectious and RASopathy diseases or disorder, for example, a cancer, by administering the said compound and combinations of the compound of formula I with other active ingredients.

Substituted tricyclic compounds

The invention relates to substituted bicyclic heterocyclic compounds of formula (I), pharmaceutically acceptable salts thereof and pharmaceutical compositions for treating diseases, disorders or conditions associated with the overexpression of PRMT5 enzyme. The invention also relates to methods of treating diseases, disorders or conditions associated with the overexpression of PRMT5 enzyme.

Substituted bicyclic heterocyclic compounds as PRMT5 inhibitors

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Pune, India

Sachin Sethi