Emcure Pharmaceuticals Limited

Sachin Arvind Badhe

Mukund Keshav Gurjar

Shashikant Gangaram Joshi

Samit Satish Mehta

Mangesh Gorakhanath Kamble

Jagannath Tulsiram Jagtap

The present invention provides a process for preparation of isoproterenol hydrochloride (1a) comprising catalytic hydrogenation of 3',4&#x2032;-dihydroxy-2-(isopropylamino)-acetophenone hydrochloride (5a) in presence of an ion exchange resin, to provide isoproterenol hydrochloride (1a).

Process for preparation of isoproterenol hydrochloride

The present invention provides a process for preparation of {(2E,4E,6E,8E)-9-(4-methoxy-2,3,6-trimethyl)phenyl-3,7-dimethyl-nona-2,4,6,8}tetraenoate, an acitretin intermediate of formula (VI) with trans isomer &#x2265;97%, comprising of reacting 3-formyl-crotonic acid butyl ester of formula (V), substantially free of impurities, with 5-(4-methoxy-2,3,6-trimethylphenyl)-3-methyl-penta-2,4-diene-1-triphenyl phosphonium bromide of formula (IV) and isolating resultant compound of formula (VI), treating the filtrate with iodine for isomerization of the undesired cis intermediate and finally obtaining acitretin (I), with desired trans isomer &#x2265;97%.

Growing community of inventors

Pune, India

Sachin Arvind Badhe