Takara Bio Inc.

Mie University

Sachiko Okamoto

Junichi Mineno

Hiroshi Shiku

Ikunoshin Kato

Tatsuji Enoki

Masanari Kitagawa

Risa Sumioka

Tomomi Otsuji

Toshikazu Nishie

Yuki Orito

Yasunori Amaishi

Risa Kato

Asako Hatsuyama

Yuka Hirase

In the present invention, lymphocytes are efficiently grown by culturing lymphocytes in the presence of a novel recombinant fibronectin fragment.

Lymphocyte production method

Stem cells can be efficiently proliferated by culturing the stem cells in the presence of a novel recombinant fibronectin fragment.

Fibronectin fragment to be used for stem cell production

Disclosed is a cell which can express a non-natural oligomeric protein, which has, introduced therein, a gene encoding an exogenous polypeptide corresponding to at least one endogenous polypeptide constituting a natural oligomeric protein, and in which the expression of the endogenous polypeptide is inhibited.

Method for expression of specific gene

Provided are a chimeric antigen receptor comprising an extracellular domain capable of binding to an antigen, a transmembrane domain and at least one intracellular domain, the chimeric antigen receptor being characterized in that an intracellular domain of a glucocorticoid-induced tumor necrosis factor receptor (GITR) is contained as the intracellular domain; a nucleic acid encoding the chimeric antigen receptor; a cell expressing the chimeric antigen receptor; and a method for producing the cell.

Chimeric antigen receptor

Growing community of inventors

Otsu, Japan

Sachiko Okamoto