Research Development Corporation of Japan

Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo

Sucampo Ag

Ueno Seiyaku Kabushikikaisha

R-tech Ueno, Ltd.

K.k. Ueno Seiyaku Oyo Kenkyujo

Sachiko Kuno

Ryuji Ueno

Ryuzo Ueno

Akihiko Tabata

Osamu Hayaishi

Tomio Oda

In one embodiment, provided is a composition including a prostaglandin compound for modulating stem cell proliferation and/or differentiation in a mammalian subject. In another embodiment, the instant application is directed to a composition which includes a prostaglandin compound for modulating proliferation and/or differentiation of stem cells of a mammalian subject, in which the stem cells are contacted directly or indirectly with the composition of the invention.

Method for modulating stem cell growth

A method for treating irritable bowel syndrome in a mammalian subject includes administering an effective amount of 13,14-dihydro-15-keto-16,16-difluoro-18-methyl-prostaglandin Eor 13,14-dihydro-15-keto-16,16-difluoro-prostaglandin E, or a salt, ether, ester or amide thereof, to the subject. A method for treating abdominal discomfort associated with irritable bowel syndrome in a mammalian subject includes administering an effective amount of 13,14-dihydro-15-keto-16,16-difluoro-18-methyl-prostaglandin Eor 13,14-dihydro-15-keto-16,16-difluoro-prostaglandin E, or a salt, ether, ester or amide thereof, to the subject.

Method for treating abdominal discomfort

A method for the treatment of ocular hypertension which comprises administering, to a subject in need of such treatment,

Treatment of ocular hypertension

The present invention relates to cathartics comprising 15-keto-16-halogen-PGs as an essential ingredient without substantive side-effects; the catharic effect is thought mainly caused by an enteropooling effect.

Prostaglandin cathartic

A method of disinfection for retroviruses which comprises contacting inanimate object in need of such treatment with a natural or synthetic oligo- or polysaccharide having at least one S-oxoacid group attached to the saccharic carbon atom through a linking group of low molecular weight.

Method of topically cleansing the human body

Method of treatment of immunodeficiency disease which comprises administering therapeutically effective amount of sex hormone to a subject in need of such treatment.

Use of sex hormone

A method of treatment of the diseases caused by AIDS virus which comprises administering an effective amount of prostaglandin biosynthesis inhibitor to a subject in need of such treatment.

Prostaglandin biosynthesis inhibitors

Method of treatment of diseases caused by retroviruses which comprises administering therapeutically effective amount of a natural or synthetic oligo- or polysaccharide having at least one S-oxoacid group attached to the saccharic carbon atom through a linking group of lower molecular weight or a pharmaceutically acceptable salt thereof to a subject in need of such treatment.

Growing community of inventors

Hyogo, Japan

Sachiko Kuno