Canon Kabushiki Kaisha

Sachiko Inoue

Fumio Yamauchi

Atsushi Takahashi

Tsutomu Honma

Yoshinori Tomida

Tatsuki Fukui

Satoshi Yuasa

Masato Minami

Satoshi Ogawa

Kengo Kanazaki

Kouichi Kato

Hideki Kaneko

Masaru Sugita

Fumiko Tomatsu

A method of detecting a contrast agent for photoacoustic imaging provides a high signal intensity. In a contrast agent for photoacoustic imaging, each particle containing an inorganic material supports at least an organic dye having an absorption coefficient in the near infrared region by means of chemical bonding.

Contrast agent for photoacoustic imaging and photoacoustic imaging method

The present invention provides a composite particle having a high molar absorption coefficient for detection with higher detection sensitivity in photoacoustic imaging. In the present invention, a composite particle having a particle, a single-chain antibody which includes an antigen recognition region and a region other than the antigen recognition region and which is conjugated with the particle, and an organic dye conjugated with the single-chain antibody, in which the region other than the antigen recognition region of the single-chain antibody has thiol group, and a functional group of the particle is bound to the thiol group, is provided.

Composite particle, contrast agent for photoacoustic imaging, and method for producing the composite particle

A user inhales medicine ejected from the medicine ejecting section of an inhaler into the air flow duct of an air flow duct forming member through a hole. As the air flow duct forming member is taken off from the inhaler body, the medicine ejecting section is covered by a cap for protection. As the air flow duct forming member is fitted to the inhaler body, the cap is opened and a sensor recognizes the open state of the cap so that the air flow duct forming member is prohibited from being fitted to and taken off from the inhaler body by a claw that is secured to the air flow duct forming member. In this way, the medicine ejecting section is prevented from being damaged when the air flow duct is fitted to and taken away from the inhaler.

Inhaler

A compound represented by Formula (1) below, where n is 2 or 3; a is an integer of 1 to 4 and b is an integer of 3 and 5 to 10, or a is 5 and b is an integer of 1 to 10; Rto Reach independently represent a hydrogen atom or a sulfonate that is any one of sodium sulfonate, potassium sulfonate, ammonium sulfonate, triethylammonium sulfonate, pyridinium sulfonate, lysine sulfonate, and arginine sulfonate; and Rto Reach independently represent a substituted or unsubstituted C1-C3 alkyl group.

Compound, probe containing the novel compound, and fluorescence-imaging contrast agent containing the novel compound or the probe

Growing community of inventors

Kawasaki, Japan

Sachiko Inoue