Taiho Pharmaceutical Company Limited

Msd K.k.

Banyu Pharmaceutical Co. Ltd

Sachie Otsuki

Takeshi Sagara

Yasuhiro Goto

Toshihiro Sakamoto

Kenji Niiyama

Keiji Takahashi

Hidetomo Furuyama

Makoto Bamba

Fuyuki Yamamoto

Hiroshi Hirai

Satoshi Sunami

Takashi Yoshizumi

Toshihide Nishibata

Satoru Ito

Katsumasa Nonoshita

Hiroshi Sootome

The present invention provides a compound represented by Formula (I) (wherein R, X, X, Y, and Z are as defined in the specification), or a salt thereof.

3,5-disubstituted alkynylbenzene compound and salt thereof

The present invention provides a new compound that has an inhibitory action against EGFR and that has cell growth inhibitory effects. The present invention further provides a pharmaceutical preparation useful for preventing and/or treating cancer, based on the EGFR inhibitory effect of the compound. A compound represented by the following Formula (I) or a salt thereof.

Quinolyl pyrrolo pyrimidyl condensed-ring compound and salt thereof

The invention relates to compounds of a general formula (I): wherein Aris an optionally-substituted aryl or heteroaromatic group; Ris an optionally-substituted lower alkyl, lower alkenyl, lower alkynyl or cyclo-lower alkyl group, or is an aryl, aralkyl or heteroaromatic group optionally having a substituent; Ris a hydrogen atom, a lower alkyl group, a lower alkenyl group or a lower alkynyl group, or is an aryl, aralkyl or heteroaromatic group optionally having a substituent; Ris a hydrogen atom or a lower alkyl group; Ris a hydrogen atom, a halogen atom, a hydroxyl group, a lower alkyl group or a group of &#x2014;N(R)R; T and U are a nitrogen atom or a methine group, etc. The compounds of the invention have excellent Weel kinase-inhibitory effect and are therefore useful in the field of medicines, especially treatment of various cancers.

Dihydropyrazolopyrimidinone derivatives

Substituted pyrazolo[3,4-d]pyrimidinone derivatives

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Tsukuba, Japan

Sachie Otsuki