Ludwig Institute for Cancer Research Limited

Cornell University

Yale University

Memorial Sloan Kettering Cancer Center

Oxford University Innovation Ltd

Icahn School of Medicine at Mount Sinai

Sacha Gnjatic

Lloyd J Old

Yao-tseng Chen

Alexander Knuth

Elke Jager

Yasuhiro Nagata

Gerd J Ritter

Jorge E Galan

Vincenzo Cerundolo

Djordje Atanackovic

Hiroyoshi Nishikawa

Khoon-Lin Ling

Romain Remark

The invention relates to the use of the type III secretion system of bacteria to stimulate immune responses against tumor antigen(s) for treating antigen-loss variant tumors. Methods are provided for stimulating and/or increasing an immune response against tumor antigens. The invention also relates to the preparation of antigen presenting cells from peripheral blood mononuclear cells using bacteria having a type III secretion system.

Methods for stimulating an immune response using bacterial antigen delivery system

The invention provides methods, compositions and kits for inducing and/or enhancing an immune response in a subject. The invention in some aspects includes polypeptide and nucleic acid molecules that induce and/or enhance an immune response. In some aspects of the invention, the polypeptide and/or nucleic acid molecules of the invention are useful to induce and/or enhance an immune response in a subject who has or is suspected of having cancer.

Method for inducing immune response to NY-CO-58

Isolated peptides are disclosed which, when processed, generate a coordinated immune response.

Method for generating an immune response and reagents therefor

The invention teaches peptide epitopes which bind to HLA-Cw3 and HLA-Cw6 molecules on the surface of cells. The peptides are useful diagnostically and therapeutically, as are DNA molecules which encode them, and the cytolytic T lymphocytes specific to the HLA/peptide complexes. Also a feature of the invention is a method for identifying relevant molecules such as those described herein, in a system that uses stimulation and restimulation using different viral vectors.

Isolated peptides which bind to HLA-C molecules and uses thereof

Growing community of inventors

New York, NY, United States of America

Sacha Gnjatic