Ludwig Institute for Cancer Research Limited

Cornell Research Foundation Inc.

Yale University

Memorial Sloan Kettering Cancer Center

Oxford University Innovation Limited

Icahn School of Medicine at Mount Sinai

Sacha Gnjatic

Lloyd J Old

Yao-tseng Chen

Alexander Knuth

Elke Jager

Yasuhiro Nagata

Gerd J Ritter

Jorge E Galan

Vincenzo Cerundolo

Djordje Atanackovic

Khoon-Lin Ling

Hiroyoshi Nishikawa

Miriam Merad

Romain Remark

The invention relates to the use of the type III secretion system of bacteria to stimulate immune responses against tumor antigen(s) for treating antigen-loss variant tumors. Methods are provided for stimulating and/or increasing an immune response against tumor antigens. The invention also relates to the preparation of antigen presenting cells from peripheral blood mononuclear cells using bacteria having a type III secretion system.

Methods for stimulating an immune response using bacterial antigen delivery system

The invention provides methods, compositions and kits for inducing and/or enhancing an immune response in a subject. The invention in some aspects includes polypeptide and nucleic acid molecules that induce and/or enhance an immune response. In some aspects of the invention, the polypeptide and/or nucleic acid molecules of the invention are useful to induce and/or enhance an immune response in a subject who has or is suspected of having cancer.

Method for inducing immune response to NY-CO-58

Isolated peptides are disclosed which, when processed, generate a coordinated immune response.

Method for generating an immune response and reagents therefor

The invention teaches peptide epitopes which bind to HLA-Cw3 and HLA-Cw6 molecules on the surface of cells. The peptides are useful diagnostically and therapeutically, as are DNA molecules which encode them, and the cytolytic T lymphocytes specific to the HLA/peptide complexes. Also a feature of the invention is a method for identifying relevant molecules such as those described herein, in a system that uses stimulation and restimulation using different viral vectors.

Isolated peptides which bind to HLA-C molecules and uses thereof

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New York, NY, United States of America

Sacha Gnjatic