Chugai Seiyaku Kabushiki Kaisha

Sapporo Breweries Limited

Oncotherapy Science, Incorporated

Saburo Sone

Takashi Tsuruo

Toyokazu Miki

Kiichi Uchida

Akito Nakamura

Masanobu Munekata

Kazumaro Seto

Masahiro Fukuoka

The present invention provides a non-human bone metastasis model animal in which tumor cells capable of inducing bone metastasis by peripheral administration have been introduced, and a method for producing the animal. The bone metastasis model animal in the present invention may be useful for understanding the biology of bone metastasis and developing novel therapeutic strategies for lung cancer patient with multi-organ metastases, including bone metastasis.

Non-human animal exhibiting bone metastasis of tumor cells

The present invention provides a non-human bone metastasis model animal in which tumor cells capable of inducing bone metastasis by peripheral administration have been introduced, and a method for producing the animal. The bone metastasis model animal in the present invention may be useful for understanding the biology of bone metastasis and developing novel therapeutic strategies for lung cancer patient with multi-organ metastases, including bone metastasis. The present invention also provides a method of screening an agent for inhibition and/or prevention of bone metastasis of tumor cells using the non-human bone metastasis model animal.

Non-human animal exhibiting bone metastasis of tumor cells and method of screening for bone metastasis inhibitors

Lymphokine activated killer suppressive factor (LAKSF) and a process for producing the LAKSF by cultivating human mono-cytic cells for alveolar macrophages activated by a stimulator to produce LAKSF and harvesting it. The LAKSF has a LAK induction suppressive activity and an immunosuppressive effect and thus the LAKSF is useful as a medicine.

Lymphokine activated killer suppressive factor (LAKSF), process for

Growing community of inventors

Tokushima, Japan

Saburo Sone