Diatheva S.r.l.

Istituto Superiore Di Sanita

Sabrina Dominici

Maurizio Cianfriglia

Valentina Fiori

Michela Flego

Alessandra Mallano

Diego Moricoli

Alessandro Ascione

Maria Cristina Balducci

Cosimo Damiano Carbonella

Maria Elena Laguardia

Silvia Zamboni

The present invention relates to a multivalent, preferably bivalent, antibody complex, more preferably a diabody, i.e. a bivalent scFv, capable of recognizing and binding the human protein CD99, a composition comprising said complex and the use thereof for diagnostic purposes and/or for the treatment and/or the follow-up of leukaemias and/or myelodysplastic syndromes. Furthermore, the present invention relates to antibodies, preferably monoclonal, of the immunoglobulins G group type capable of recognizing and binding the human protein CD99, a composition comprising said immunoglobulins and the medical use thereof, in particular for the treatment and/or the follow-up of cancer, preferably solid tumours that express CD99 and/or leukaemias and/or myelodysplastic syndromes.

Antibody complex and uses thereof

Growing community of inventors

Fermignano, Italy

Sabrina Dominici