Phadia Ab

Biomay Ag

Sabine Stumvoll

Rudolf Valenta

Dietrich Kraft

Peter Valent

Paolo Colombo

Susanne Vrtala

Wolfgang R Sperr

Hans Grönlund

Kerstin Westritschnig

Birgit Linhart

Luca Vangelista

Monika Grote

Annalisa Pastore

Susanne Spitzauer

Nadine Mothes

Margit Focke

Maria-Theresa Krauth

Domenico Geraci

Giovanni Duro

Methods for desensitization of a mammal suffering from IgE mediated allergy comprise the steps of: administering to said mammal a therapeutically effective amount of an immunogenic and hypoallergenic composition which comprises (i) a Phl p 6 molecule having an N-terminal truncation which makes the molecule at least lack IgE binding capacity, and/or (ii) a Phl p 6 molecule having a C-terminal truncation which makes the molecule at least lack IgE binding capacity, wherein the molecules of (i) and (ii), if employed in combination, together span the complete sequence of Phl p 6, and a pharmaceutically acceptable carrier.

Non-anaphylactic forms of grass pollen Ph1 p 6 allergen and their use

A process for the preparation of an hypoallergenic mosaic antigen derived from an allergen is disclosed whereby a) in a first step the allergen is split into at least two parts and the IgE reactivity of each part is determined and b) in a second step those parts of the allergen which have no detectable IgE reaction are combined to a mosaic antigen which comprises the amino acids of the allergen but the order of the amino acids of the mosaic antigen is different from that of the naturally occurring allergen.

Process for the preparation of hypoallergenic mosaic antigens

Growing community of inventors

St. Peter, Austria

Sabine Stumvoll