Institut National De La Recherche Agronomique

Institut National De La Recherche Agronomique (inra)

Sabine Riffault

Jean-François Eleouët

The invention relates to N protein-protein of interest fusion proteins, optionally in the form of soluble N protein-protein of interest/P protein complexes, the N and P proteins being proteins of a virus of the Paramyxoviridae family. When the protein of interest is an antigen, the invention relates also to vaccinal compositions and diagnostic reagents comprising those N protein-antigen fusion proteins or those N protein-antigen/P protein complexes. The N protein-protein of interest fusion protein can also be used as a 'vector' for transporting into cells therapeutic molecules of interest, such as antivirals or anticancer agents.

N protein of a virus of the paramyxoviridae family-protein of interest fusion proteins

The invention relates to a method for preparation of soluble N-protein/truncated P-protein complex of a virus of the family Paramyxoviridae, complexes prepared thus and the soluble N-proteins which may be isolated from said complexes. The invention further relates to vaccine compositions comprising said N-protein/truncated P-protein complexes or N-proteins from Paramyxoviridae.

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Jouy en Josas, France

Sabine Riffault