3d Signatures Holdings Inc.

3d Signatures Inc.

Cancercare Manitoba

University of Manitoba

Telo Genomics Holdings Corp.

Sabine Mai

Yuval Garini

Sjoerd Stallinga

Yvon E Cayre

Lucas Jozef Van Vliet

Macoura Gadji

Christiaan Righolt

Angeles Garcia

Ade Olujohungbe

Rahul Sarkar

Bartholomeus J Vermolen

Tony Chih Yuan Chuang

Sharareh Moshir

Hans Knecht

Ian T Young

Tony Chih Chuang

Janine Wechsler

Provided are methods for prognosing a clinical outcome in a subject with a hematological disorder comprising determining a 3D telomeres organization signature of a test sample cell from the subject, wherein the 3D telomeres organization signature of the test sample cell is indicative of the clinical outcome of the subject.

Hematological disorder diagnosis by 3D q-FISH

A method of measuring a characteristic optionally a clinical characteristic of a cancer test cell sample comprising: characterizing nuclear organization of DNA of the test cell sample: obtaining DNA image data of the cancer test cell sample nuclei using microscopy, processing the image data using granulometry to obtain one or more data points corresponding to DNA occupied space and/or DNA low space; and quantifying a feature of the DNA occupied space and/or a feature of the DNA low space.

Methods for assessing cancer cells using granulometry

A method for diagnosing and/or evaluating dementia severity in a subject suspected of having or having dementia is provided the method comprising:

Methods for evaluating Alzheimer's disease and disease severity

The present application relates to a method of detecting and monitoring cancer or precancer in a cell using three-dimensional analysis to assess centromere organization. In addition, the application relates to a method and system for characterizing the 3D organization of centromeres.

Methods of detecting and monitoring cancer using 3D analysis of centromeres

The present invention relates to a method of detecting and monitoring genomic instability in a cell using three-dimensional analysis to assess telomeric and/or chromosomal organization. In addition, the invention relates to a method and system for characterizing the 3D organization of telomeres and/or chromosomes. The system includes an input module for inputting image data of the 3D organization of telomeres and/or chromosomes and a characteristic module for finding a parameter of the 3D organization. The invention also relates to the use of the three-dimensional analysis to detect, diagnose or monitor disease, particularly proliferative diseases such as cancer.

Method of monitoring genomic instability using 3D microscopy and analysis

There is provided a method for identifying pre-malignancy, malignancy, and degree of pre-malignancy and malignancy of a cell by detecting extrachromosomal and intrachromosomal gene amplification. Also provided is a marker for the identification of pre-malignancy, malignancy, and degree of pre-malignancy and malignancy of a cell containing extrachromosomal and intrachromosomal gene amplification of a gene. A diagnostic tool for the diagnosis and prognosis or cervical cancer containing extrachromosomal and intrachromosomal gene amplification of a gene.

Method and marker for identification of pre-malignancy and malignancy and therapeutic intervention

Growing community of inventors

Winnipeg, Canada

Sabine Mai