Bayer Aktiengesellschaft

Bayer Healthcare LLC

Sabine Hoff

Uwe Gritzan

Sandra Berndt

Dieter Zopf

Christian Votsmeier

Lars Röse

Fabian Kiessling

Katharina Filarsky

Wiebke Maria Nadler

Su-Yi Tseng

Wiltrud Lederle

Dennis Doleschel

Helge Roider

Beatrix Stelte-Ludwig

Ernst Weber

Mark Trautwein

Nikolaus Pawlowski

Oliver Von Ahsen

Philipp Ellinger

Matyas Gorjanacz

Patrick Jones

Christian Bertling

Pascale Buchmann

Pedro Paz

Phaik Lyn Oh

The present invention relates to tools and methods for the generation of antibodies which specifically bind chemokine receptors, such as CC or CXC chemokine receptors. Provided are isolated sulfated polypeptides and conjugates thereof, which can be used for example as antigens or for off target panning to facilitate the generation of anti-human, anti-, and/or anti-mouse chemokine receptor antibodies, e.g. for the generation of antibodies with fully human CDRs and/or other favorable properties for therapeutic use. The present invention furthermore relates to antibodies and conjugates thereof which can be obtained by applying the aforementioned tools and methods. Provided are antibodies specifically binding to human,and/or murine CCR8 with favorable properties for therapeutic use, such as cross-reactive antibodies, fully human antibodies, low internalizing (including non-internalizing) antibodies, and antibodies efficiently inducing ADCC and/or ADCP in Treg cells.

Methods of treatment using CCR8 antibodies

The present invention relates to pharmaceutical compositions and combinations comprising regorafenib or its hydrate, solvate, metabolite or pharmaceutically acceptable salt or a polymorph thereof and a PD-1/PD-L1(2) inhibitor for treating, preventing or managing diseases and conditions including hyperproliferative disorders such as cancer in humans and other mammals.

Combination of regorafenib and PD-1/PD-L1(2) inhibitors for treating cancer

The present invention relates to tools and methods for the generation of antibodies which specifically bind chemokine receptors, such as CC or CXC chemokine receptors. Provided are isolated sulfated polypeptides and conjugates thereof, which can be used for example as antigens or for off target panning to facilitate the generation of anti-human, anti-cynomolgus, and/or anti-mouse chemokine receptor antibodies, e.g. for the generation of antibodies with fully human CDRs and/or other favorable properties for therapeutic use. The present invention furthermore relates to antibodies and conjugates thereof which can be obtained by applying the aforementioned tools and methods. Provided are antibodies specifically binding to human, cynomolgus and/or murine CCR8 with favorable properties for therapeutic use, such as cross-reactive antibodies, fully human antibodies, low internalizing (including non-internalizing) antibodies, and antibodies efficiently inducing ADCC and/or ADCP in Treg cells.

CCR8 antibodies for therapeutic applications

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Potsdam, Germany

Sabine Hoff