Gruenenthal Gmbh

Gruenethal Gmbh

Grunenthal Gmbh

Sabine Hees

Ruth Jostock

Melanie Reich

Stefan Schunk

Tieno Germann

Stefan Oberboersch

Michael Engels

Klaus Schiene

Beatrix Merla

Edward Bijsterveld

Jean De Vry

Michael Franz-Martin Engels

Thomas Christoph

Achim Kless

Bernd Sundermann

Werner Guenter Englberger

Heinz Graubaum

Fritz Theil

Stefan Oberbörsch

Timo Struenker

Ellen Klegraf

Kamila Hennig

Timo Strünker

Substituted sulfonamide compounds with bradykinin receptor (B1R) modulating activity; processes for the preparation thereof, pharmaceutical compositions comprising such compounds, and methods of using such compounds to treat or inhibit pain and/or other disorders and/or disease states.

Substituted sulfonamide compounds

Substituted sulfonamide compounds corresponding to the formula I processes for the preparation thereof, pharmaceutical compositions containing these compounds and the use of substituted sulfonamide compounds for the preparation of pharmaceutical compositions for treating pain and other conditions at least partly mediated via the bradykinin 1 receptor.

Substituted indole compounds corresponding to the formula I: In which R, R, R, R, R, R, R, A, D, T, q, s and t have defined meanings, processes for the preparation thereof, pharmaceutical compositions containing such compounds and the use of substituted indole compounds for the treatment or inhibition of pain and other conditions which are at least partly mediated by Bradykinin 1 receptors (B1R).

Substituted indole compounds

Substituted sulfonamide derivatives, a process for their preparation, pharmaceutical compositions containing these compounds, and to the use of substituted sulfonamide derivatives in the treatment or inhibition of pain and/or various disorders or disease states.

Substituted spiroamide compounds corresponding to formula (I): wherein A, B, Q, Q, Q, Q, R, R, R, R, R, R, Rand Rhave defined meanings, processes for their preparation, pharmaceutical compositions containing such compounds, and the use of such compounds for treating or inhibiting pain or other conditions mediated at least in part by the bradykinin 1 receptor (B1R).

Spiro group-containing amide compounds having bradykinin 1 receptor (B1R) activity

Substituted sulfonamide compounds corresponding to formula I: processes for the preparation thereof, pharmaceutical compositions containing these compounds, and the use of such substituted sulfonamide compounds in pharmaceutical compositions for the treatment and/or inhibition of pain and other conditions at least partly mediated by the bradykinin 1 receptor.

Substituted spiroamine compounds corresponding to the formula (I) In which m, n, o, p, Q, r, s, t, R, R, R, R, R, R, R, R, R, R, R, R, Rand Rhave defined meanings; a process for the preparation of such compounds, pharmaceutical compositions containing such compounds and the use of substituted spiroamines for the treatment or inhibition of pain and/or other conditions mediated by the bradykinin 1 receptor.

Substituted spiroamine compounds

Substituted pyrimidine and triazine compounds corresponding to formula I wherein R, R, R, R, R, R, R, R, R, R, R, R, R, A, a, b, s, t, V, W, Wand Whave defined meanings, pharmaceutical compositions comprising such compounds, a process for preparing such compounds, and the use of such compounds and compositions to treat or inhibit pain and/or other disorders or disease states.

Substituted pyrimidine and triazine compounds

Substituted sulfonamide compounds corresponding to formula I processes for the preparation thereof, pharmaceutical compositions containing such compounds, and the use of such compounds for treating and/or inhibiting pain or other conditions at least partly mediated by the bradykinin 1 receptor.

Substituted sulfonamide compounds corresponding to the formula I wherein m, n, p, Q, R, R, R, R, X, Y and Z have the respective meanings defined herein, pharmaceutical compositions containing such compounds, a process for their preparation, and the use of such compounds for the treatment and/or inhibition of pain and other conditions mediated by bradykinin receptor 1 (B1R) and/or bradykinin receptor 2 (B2R).

Substituted benzimidazoles, benzothiazoles and benzoxazoles, processes for their preparation, pharmaceutical compostions containing these compounds and the use of these compounds for treating or inhibiting disorders or disease states mediated at least in part by bradykinin receptor 1 (BR1).

Substituted benzimidazoles, benzothiazoles and benzoxazoles

Substituted sulfonamide compounds corresponding to the formula I' wherein m, n, p, X, Y, Z, R1, RA and RB have specified meanings, processes for their preparation, pharmaceutical compositions containing these compounds, and the use of these substituted sulfonamide compounds for the treatment and/or inhibition of pain or other conditions.

Substituted sulfonamide compounds having bradykinin 1 receptor activity and use thereof as medicaments

Sulfonylated tetrahydroazolopyrazine compounds corresponding to the formula I wherein R, R, R, R, R, R, R, R, R, R, R, A, B, W, Wand Whave the meanings defined herein, pharmaceutical compositions containing such compounds, a method for the preparation of such compounds, and the use of such compounds for treating or inhibiting various types of pain and/or other conditions mediated at least in part by the bradykinin 1 receptor (B1R).

Sulfonylated 1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine compounds and their use as pharmaceuticals

Substituted sulfonamide compounds corresponding to formula I: a process for their preparation, pharmaceutical compositions comprising such compounds, and the use of such substituted sulfonamide compounds in pharmaceutical compositions for the treatment of pain or other disorders or diseases that are mediated at least in part by B1R receptors.

Substituted disulfonamide compounds corresponding to formula I: In which R, R, R, R, R, R, R, R, R, R, R, R, a, b, s, t and A have defined meanings, pharmaceutical compositions containing one or more such compounds, processes for preparing such compounds, and a method of using such compounds for the treatment or inhibition of pain and/or other conditions mediated by the bradykinin receptor 1 (BR1).

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Aachen, Germany

Sabine Hees