Tel Aviv University

Saar Oz

Illana Gozes

Jacqueline Woang Cheing Tiong

Inna Divinski

Maya Maor

David Dangoor

This invention provides novel compounds and methods for promoting cell survival and/or plasticity, especially in neuronal cells, by targeting the microtubule End Binding (EB) proteins and other associated proteins (e.g., drebrin). Methods for identifying potential modulators of cell death/plasticity are also described.

Method for identifying a modulator of cell survival or plasticity

Compounds and methods for inhibiting cell death

The invention is based on the discovery of a novel neuroprotective peptide. In addition, the invention rests on the discovery that the NAP peptide enhances the association of tau and the brain-specific beta tubulin subunit. In addition, NAP modifies microtubule assembly and dynamics, in part, by affecting the tyrosination of microtubule proteins. The invention provides compositions and methods for treatment and prevention of neuronal disorders, including NAP-binding and tau-binding agents, tau peptide mimetics, NAP-like and NAP-like tau peptide mimetics.

Therapeutics based on tau/microtubule dynamics

Growing community of inventors

Ramat-Hasharon, Israel

Saar Oz