Allegheny-singer Research Institute

Carnegie Mellon University

Franklin and Marshall College

Oklahoma State University

Saadyah Averick

Krzysztof A Matyjaszewski

Ryan Aaron Mehl

Toby Larue Nelson

Subha Ranjan Das

Andrew Kassick

Boyle Cheng

Bruce Alan Armitage

Munira F Fouz

Keith Lejeune

Santosh Adhikari

Michael Oh

Shaohua Li

Donald M Whiting

Antonina Simakova

Ahmed Badr

Bertram Richter

Sourav K Dey

Polymer conjugates comprising a hydrophobic biodegradable polymer covalently attached to a mu opioid receptor (MOR) antagonist are described. Biodegradable covalent nanoparticles comprising the hydrophobic biodegradable polymer covalently attached to a MOR antagonist are provided as a vehicle for the sustained delivery of the MOR antagonist. The described MOR antagonist delivery system may be used to more effectively prevent or overcome the toxic effects of synthetic opioids.

Covalent modification and controlled delivery of mu opioid receptor antagonists

This patent document discloses a modified polymer having increased hydrophilicity and a method of preparing the same. A polyarylene ether ketone polymer having a plurality of repeating units, wherein one or more units of the plurality of repeating units contains a hydrophilic N-substituted imine, which is derived from a ketone in the one or more units.

Hydrophilic polyarylene ether ketone polymer and methods of forming same

This patent document discloses a method of fabricating an electrically conductive fiber coated with polythiophene and a carbon material. The low-cost method is amenable to modifications to suit the practical needs in various applications.

Preparation and characterization of organic conductive threads as non-metallic electrodes and interconnects

This document discloses an electrically conductive fiber coated with polythiophene and a carbon material. Also disclosed is an article of manufacture incorporating the conductive fiber.

Conductive fiber with polythiophene coating

Various fentanyl derivatives are described. The derivatives exhibit high binding affinity to opioid receptors, but also have decreased blood brain permeability as compared to standard fentanyl. This, the resulting derivatives can be less addictive than standard fentanyl. Methods of making such derivatives are also disclosed in this document.

Hydrophilic fentanyl derivatives

A composition includes a polymer including extending chains, side chains, or branches. One (or more) of a plurality of a first strand of nucleic acid is attached to each of a plurality of the side chains. One (or more) of a plurality of a second strand of nucleic acid, which is complementary to the first strand of nucleic acid, is complexed to each of the plurality of the first strand of nucleic acid to form a double strand of nucleic acid on each of the plurality of the side chains. At least one fluorescent compound is associated with the double strand of nucleic acid on each of the plurality of the side chains.

Nucleic acid-polymer conjugates for bright fluorescent tags

Methods for conducting controlled grafting-from radical polymerizations from biomolecules under conditions that are biologically compatible are described. The methods provide biomolecule-polymer conjugates with highly controlled structures and narrow polydispersities under aqueous reaction conditions and biological temperatures. Biomolecules, such as proteins and nucleotides can be conjugated to polymers with high levels of control.

Atom transfer radical polymerization under biologically compatible conditions

The present invention is directed towards a protein-polymer composition having a protein with a site-specifically incorporated unnatural amino acid initiator and a covalently attached polymer.

Site specifically incorporated initiator for growth of polymers from proteins

A method of synthesizing a polynucleotide composition includes attaching a compound including at least one initiator or at least one transfer agent for a reversible deactivation radical polymerization to an end of a nucleotide chain assembly immobilized upon a solid phase support during a solid phase synthesis of a polynucleotide so that the initiator or the transfer agent is attacked to the end of a nucleotide chain assembly in a manner which is stable under conditions of deprotection of the polynucleotide, and growing a polymer from the initiator of from a site of the chain transfer agent via the reversible deactivation radical polymerization to form the polynucleotide composition.

Functionalized polymer hybrids

This invention pertains to methods for producing homogeneous recombinant proteins that contain polymer initiators at defined sites. The unnatural amino acid, 4-(2'-bromoisobutyramido)phenylalanine of formula 1, was designed and synthesized as a molecule comprising a functional group further comprising an initiator for an atom-transfer radical polymerization ('ATRP') that additionally would provide a stable linkage between the protein and growing polymer. We evolved a(Mj) tyrosyl-tRNA synthetase/tRNApair to genetically encode this unnatural amino acid in response to an amber codon. To demonstrate the utility of this functional amino acid, we produced Green Fluorescent Protein with the unnatural amino acid initiator of formula 1 site-specifically incorporated on its surface (GFP-1). Purified GFP-1 was then used as an initiator under standard ATRP conditions with oligo(ethylene oxide)monomethyl ether methacrylate, efficiently producing a polymer-GFP bioconjugate wherein the polymer is connected at a specifically selected site on GFP.

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Pittsburgh, PA, United States of America

Saadyah Averick