Other

Saadiq El-Amin

Harry R Allcock

Cato T Laurencin

Archel M A Ambrosio

Shawn R Pucher

A highly porous three-dimensional biodegradable poly(organophosphazene) matrix with hydrolytically unstable side chains is prepared and used as a scaffold for the growth of osteoblast cells. In a preferred embodiment, the poly(organophosphazene) includes between 10 and 90% hydrolytically unstable side chains including glucosyl, glyceryl, glyceryl, imidazolyl or ethoxy units, for example, poly&lsqb;(methylphenoxy)(ethyl glycinato) phosphazene&rsqb;. The addition of the glucosyl, glycinyl or glyceryl side chains to the polymer can also be used generally to enhance growth rates of cells adhered to the polymer, presumably through uptake and metabolism of the simple sugar or alcohol units.

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Brighton, MA, United States of America

Saadiq El-Amin