The Brigham and Women's Hospital, Inc.

Massachusetts Institute of Technology

The General Hospital Corporation

Translational Research Institute Pty Ltd as Trustee of Translational Research Institute Trust

Datchem Pty Ltd

Saadallah Ramadan

Carolyn Mountford

Elfar Adalsteinsson

Alma Gregory Sorensen

Borjan Aleksandar Gagoski

Alexander P Lin

Ovidiu Andronesi

Robert Stern

Gorane Santamaria

David Clarke

Peter Malycha

A method and system for detecting the presence of BRCS carriers in breast tissue, comprises obtaining spectral data from breast tissue using a magnetic resonance spectroscopy device and producing spectral data by said device which provides chemical markers to enable detection of whether the breast tissue contains BRCA carriers.

Detection of BRCA and other high risk carriers in breast tissue

A method for producing a biomarker indicative of a repetitive head injury in a subject using a magnetic resonance imaging (MRI) system is provided. Two-dimensional spectroscopic data is acquired from a subject using an MRI system. From the two-dimensional spectroscopic data, a two-dimensional spectrum is produced. The two-dimensional spectrum contains spectral information indicated by a first spectral dimension and a second spectral dimension. Such a two-dimensional spectrum may include diagonal peaks and off-diagonal, or cross-peaks. In such an instance, each cross peak may indicate, for example, scalar coupling between the two protons it connects on the diagonal. However, depending on the type of method used, different types of coupling may also be present. Using the two-dimensional spectrum, a biomarker indicative of repetitive head injury in the subject is identified, and may be used to produce a report indicating a status or regression of a neurological dysfunction.

Method for assessing repetitive head injuries with two-dimensional magnetic resonance spectroscopy

Methods for low-power in vivo localized multi-dimensional correlated magnetic resonance spectroscopy ('MRS') are provided. Low-power adiabaticity is achieved, generally, using gradient-modulated radio frequency pulses for localization and mixing. The provided pulse sequences also provide a mechanism for longitudinal mixing, which significantly increases the efficiency of magnetization transfer and thereby increases signal-to-noise ratio.

Method for two-dimensional correlation magnetic resonance spectroscopy

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Bexley, Australia

Saadallah Ramadan