Samyang Biopharmaceuticals Corporation

Samyang Corporation

Sa-Won Lee

Min-Hyo Seo

Joong-Woong Cho

Gyeong-Hae Kim

Jeong-Kyung Kim

Jeong-Il Yu

Min Hyo Seo

In-Ja Choi

Bong-Oh Kim

Hye-Jeong Yoon

Myung-Seob Shim

Yil-Woong Yi

Hee-Jo Kim

Jae-Hong Kim

Myung-Han Huyn

Dong-Hoon Chang

Myung-Han Hyun

Jung-Il Yu

Hye-Won Kang

Provided are a composition containing an unstable drug against oxidation like pemetrexed with improved stability and a preparation method thereof, by removing oxygen during the preparation. The method is readily applicable for manufacturing by freezing and degassing in a sealed chamber, and can provide formulations with significantly increased stability for the unstable drug against oxidation.

Stabilized pharmaceutical composition and method for preparing same

Provided are a composition containing an unstable drug against oxidation like pemetrexed with improved stability and a preparation method thereof, by removing oxygen during the preparation without use of an antioxidant. The method is readily applicable for manufacturing by freezing and degassing in a sealed chamber, and can provide formulations with significantly increased stability for the unstable drug against oxidation.

Pharmaceutical composition not containing antioxidant and preparation method therefor

A method for stabilizing a poorly water-soluble drug-containing amphiphilic block copolymer micelle composition via simplified steps in short time is described. Also described is a stabilized poorly water-soluble drug-containing amphiphilic block copolymer micelle composition having improved stability.

Method for stabilizing amphiphilic block copolymer micelle composition containing poorly water-soluble drug

Disclosed are a polymeric drug carrier-containing pharmaceutical composition with enhanced stability in its solution state and a method for stabilizing the same. More particularly, disclosed are a pharmaceutical aqueous solution composition for storage under refrigeration containing a polymeric drug carrier comprising an amphiphilic block copolymer comprised of a hydrophilic block and a hydrophobic block, and a polylactic acid derivative fixed with a di- or tri-valent metal ion at its terminal carboxyl group and having preservation stability for at least 6 months, preferably at least 12 months when stored under refrigeration, and a method for stabilizing the same.

Polymeric nanoparticle solution composition and its manufacturing process

The present invention relates to an amphiphilic block copolymer of a hydrophilic block and a hydrophobic block with a terminal hydroxyl group wherein the terminal hydroxyl group of the hydrophobic bock is substituted with a tocopherol or cholesterol group. It also relates to polymeric compositions capable of forming stable micelles in an aqueous solution, comprising the amphiphilic block copolymer and a polylactic acid derivative wherein one or more ends of the polylactic acid are covalently bound to at least one carboxyl group.

Amphiphilic block copolymer and polymeric composition comprising the same for drug delivery

Polymeric compositions capable of forming stable micelles in an aqueous solution, comprising an amphiphilic block copolymer of a hydrophilic block and a hydrophobic block, and a polylactic acid derivative wherein one end of the polylactic acid is covalently bound to at least one carboxyl group. The carboxyl group of the polylactic acid derivative may be fixed with a di- or tri-valent metal ion, obtained by adding the di- or tri-valent metal ion to the polymeric composition.

Polymeric micelle compositions with improved stability and methods of making thereof

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Daejeon, South Korea

Sa-Won Lee