Implant Sciences Corporation

Saïd Boumsellek

Dmitriy Ivashin

Thomas J Kuehn

Dmitriy V Ivashin

A tandem instrument using a variable frequency pulsed ionization source and two separation techniques, low (IMS) and high (FAIMS) field mobility is provided. The analytical stage features a field driven FAIMS cell embedded on-axis within the IMS drift tube. The FAIMS cell includes two parallel grids of approximately the same diameter as the IMS rings and can be placed anywhere along the drift tube and biased according to their location in the voltage divider ladder to create the same IMS field. The spacing between the grids constitutes the analytical gap where ions are subject, in addition to the drift field, to the asymmetric dispersive field of the FAIMS. The oscillatory motion performed during the high and low voltages of the asymmetric waveform separates the ions according to the difference in their mobilities.

Ion mobility spectrometer device with embedded faims

Using combined orthogonal techniques, such as low (IMS) and high (FAIMS) field mobility techniques, offers several advantages to ion detection and analysis techniques including low cost, no vacuum required, and the generation of 2-D spectra for enhanced detection and identification. Two analytical devices may be operated in different modes, which results in overall flexibility by adapting the hyphenated instrument to the application's requirements. With the IMS-FAIMS hardware level flexibility, the instruments may be configured and optimized to exploit different trade-offs suitable for a variety of detection scenarios of for different lists of target compounds.

Chemical analysis using hyphenated low and high field ion mobility

A trace detection system includes at least two stages coupled to operate in series. An ion mobility spectrometer (IMS) stage has a sampling inlet to receive a sample to be analyzed. An ion source ionizes the sample. The IMS applies an electrical field to the ionized sample to move the ionized sample toward an IMS outlet. A differential mobility spectrometer (DMS) stage coupled in series with the IMS stage receives the ionized sample from the IMS stage. Preferably, the system includes a mass spectrometer (MS) stage coupled in series with the DMS stage to receive the ionized sample from the DMS stage via a vacuum interface. A roughing vacuum pump evacuates a first stage of the MS stage to a first pressure below atmospheric pressure. A high vacuum pump evacuates a second stage of the MS stage to a second pressure below the first pressure.

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San Diego, CA, United States of America

Saïd Boumsellek