Endocon, Inc.

Engineering Development Associates, Ltd.

S Mitchell Harman

Robert J Leonard

A bioerodible pellet capable of administering an even and continuous dose of a peptide over a period of up to a year, when subcutaneously implanted, is provided. The bioerodible implant is a partially-fused pellet, which pellet has a peptide drug homogeneously-bound in a matrix of a melted and recrystallized, nonpolymer carrier. Preferably, the nonpolymer carrier is a steroid and in particular is cholesterol or a cholesterol derivative. In one embodiment, the peptide drug is growth hormone-releasing hormone. A method for making the bioerodible pellet also is provided.

Manufacture of partially fused peptide pellet

Partially fused peptide pellet

A device for subcutaneous implantation of a plurality of solid, elongated medicinal pellets. The device includes a needle-like, hollow cannula within a barrel. The hub has a manually engageable knob thereon so that the hub and cannula may be easily moved with respect to the barrel with the thumb of one hand during the implantation process. An obturator extends from the rear of the barrel into the proximal end of the cannula. The obturator is composed of two or more sections which allow it to telescope during operation.

Injector for inplanting multiple pellet medicaments

Injector for implanting multiple pellet medicaments

An improved magazine type implant injector having a slotted barrel element slidably mounting an integral magazine element and cannula. The barrel element mounts an obturator which projects into the magazine element to serially advance elongated implants to the cannula, each implant advancing a previously engaged implant through the distal end of the cannula for implantation.

Growing community of inventors

Ellicott City, MD, United States of America

S Mitchell Harman