Irm LLC

S Frank Yan

Qiang Ding

Xu Wu

Qihui Jin

Yahua Liu

Jianwei Che

Tetsuo Uno

Yunho Jin

Barun Okram

Xueshi Hao

The invention provides a novel class of 2,7-naphthyridin derivatives; pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly Syk, ZAP70, KDR, FMS, FLT3, c-Kit, RET, TrkA, TrkB, TrkC-GR-1R, Alk, c-FMS, or combinations thereof.

Compounds and compositions as kinase inhibitors

The invention provides a class of compounds of Formula (I), pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly Syk, ZAP70, KDR, FMS, FLT3, c-Kit, RET, TrkA, TrkB, TrkC, IGR-IR, AIk, c-FMS, or combinations thereof. 

Pyrido [4, 3-D] pyrimidinone derivatives as kinase inhibitors

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Shanghai, China

S Frank Yan