Fred Hutchinson Cancer Center

Presage Biosciences, Inc.

Polybiomics, Inc.

Fred Hutchinson Cancer Research Center

S Bahram Bahrami

Mandana Veiseh

James M Olson

Pirooz Parvarandeh

Oliver Peter King-Smith

Todd S Rutherford

Aaron Peter Schellenberg

Timothy Scott Edward Hiller

James Olson

Toward forming a single hybrid biosensing-imaging system that can operate inside an incubator, structures and methods are directed to placing modular and removable biosensors and biocompatible interfaces in 3D transparent test wells that contain biological samples. The technology enables continuous monitoring of multiple simultaneous parameters and functions of a living cell or cell clusters such as alterations of cellular ligands, physicochemical biomarkers, phenotypes, and/or extracellular compositions upon interactions with analytes or during progressions. Methods of capturing and analyzing direct orthogonal information from biological samples in 2D and 3D, which are conducive to generating new insights are presented.

Orthogonal polybiosensing and imaging systems

A fluid delivery device includes an array of needles, each in fluid communication with a respective reservoir. Respective actuators are coupled so as to be operable to drive fluid from the reservoirs via needle ports. Each needle can have a plurality of ports, and the ports can be arranged to deliver a substantially equal amount of fluid at any given location along its length. A driver is coupled to the actuators to selectively control the rate, volume, and direction of flow of fluid through the needles. The device can simultaneously deliver a plurality of fluid agents along respective axes in solid tissue in vivo. If thereafter resected, the tissue can be sectioned for evaluation of an effect of each agent on the tissue, and based on the evaluation, candidate agents selected or deselected for clinical trials or therapy, and subjects selected or deselected for clinical trials or therapeutic treatment.

Needle array assembly and method for delivering therapeutic agents

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Emeryville, CA, United States of America

S Bahram Bahrami