Max-delbruck-centrum Fur Molekulare Medizin

Biomet Deutschland Gmbh

Dentsply Sirona Inc.

Sirona Dental Systems Gmbh

Régis Cartier

Annekathrin Haberland

Henrich Mannel

Michael Böttger

Regins Reszka

Norbert Baranowski

The present invention relates to an implant having a surface comprising a coating on at least a portion of the surface of the implant, wherein the coating comprises at least two coating layers of bioactive compounds adjacent to each other, obtainable in a process comprising the following steps: providing an implant with a surface, providing a first suspension comprising at least one first bioactive compound in a first solvent, wherein the first bioactive compound is non-soluble or partially soluble in the first solvent, applying said first suspension comprising the at least one first bioactive compound onto at least a part of the implant surface forming a first coating layer; drying the first coating layer, providing a second solution comprising at least one second bioactive compound in a second solvent, wherein the second bioactive compound is soluble or readily soluble in the second solvent; applying said second solution comprising the at least one second bioactive compound onto the first coating layer forming a second coating layer, and drying the second coating layer.

Implant with an bioactive coating and method for providing the same

The invention relates to a method for improving transfection efficiency through the use of K16-peptides. In addition, the invention further relates to novel K16-peptides, including a K16-CYC peptide.

Method for improving transfection efficiency

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Berlin, Germany

Régis Cartier