Astellas Pharma Gmbh

Yamanouchi Pharmaceutical Company Ltd.

Ryutaro Wakayama

Hiroshi Nagata

Fukushi Hirayama

Yuji Koga

Keizo Sugasawa

Susumu Watanuki

Masaaki Hirano

Minoru Okada

Hiroyuki Moritomo

Norio Seki

Eiji Kawaminami

Ken-Ichi Suzuki

Akira Toyoshima

Toshiyuki Kusayama

Toru Watanabe

Hideki Kubota

Hiroyuki Koshio

Hidenori Azami

Issei Tsukamoto

Ippei Sato

Yuta Fukuda

Akio Kakefuda

Kazuyoshi Obitsu

Ken-ichi Suzuki

Masanao Sanagi

Susumu Toda

Kazuki Ono

A 2-acylaminothiazole derivative or a pharmaceutically acceptable salt thereof having an excellent effect of proliferating human c-mpl-Ba/F3 cells and an activity of increasing platelets based on the effect of promoting the formation of megakaryocytic colonies. A compound or a pharmaceutically acceptable salt thereof useful in treating thrombocytopenia.

2-acylaminothiazole derivative or salt thereof

A compound that can be used as an agent for treating a disease associated with an EP1 receptor, in particular a lower urinary tract symptom. It was confirmed that a sulfonamide compound having an amide structure and characterized by a chemical structure in which a carbon atom in the amide bonds to the N atom in sulfonamide through lower alkylene, or a salt thereof, has a potent EP1 receptor antagonistic activity, accomplishing the present invention. Since the sulfonamide compound of the present invention or a pharmaceutically acceptable salt thereof has a potent EP1 receptor antagonistic activity, it is useful as an agent for treating a disease associated with an EP1 receptor, in particular, a lower urinary tract symptom.

Sulfonamide compound or salt thereof

2-Acylaminothiazole derivative or salt thereof

Provided is a pharmaceutical composition containing a propane-1,3-dione derivative as the active ingredient, particularly a GnRH receptor antagonist. Also, provided is a propane-1,3-dione derivative having a GnRH antagonistic effect.

Propane-1, 3-dione derivative

To provide a compound having a superior arginine vasopressin antagonism. A novel 1,4,5,6-tetrahydroimidazo[4,5-d]benzazepine derivative or a pharmaceutically acceptable salt thereof.

1,4,5.6-tetrahydroimidazo[4,5-d]diazepine derivatives or salts thereof

Propane-1,3-dione derivative

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Tsukuba, Japan

Ryutaro Wakayama