Yamanouchi Pharmaceutical Company Ltd.

Ryutaro Kawai

Masuo Murakami

Masaru Iwanami

Tadao Shibanuma

Masaharu Fujimoto

Norio Sato

Kozo Takahashi

Toichi Takenaka

Kuniichiro Yano

Teruaki Ozasa

Kazuharu Tamazawa

Novel 1-substituted-1, 4-dihydropyridine derivatives, particularly diethyl 1-ethoxymethyl-4-(3-nitrophenyl)-2, 6-dimethyl-1, 4-dihydropyridine-3,5-dicarboxylate are provided. The novel derivatives have cerebral vascular dilator activity with low toxicity.

Sodium

N-alkenyltetracycline derivatives, for example, N-(1-methyl-2-.alpha.-naphthylethenyl)tetracycline represented by the formula ##SPC1## The compounds have excellent antibacterial action as compared with tetracycline.

N-alkenyltetracycline derivatives

There are provided novel 1,4-dihydropyridine derivatives, particularly 2,6-dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-.beta.-(N-benzyl-N-methylamino)ethyl ester and 5-methyl ester. The 1,4-dihydropyridine derivatives are characterized by cerebral vascular dilator activity.

1,4-Dihydropyridine derivatives

N-alkenyltetracycline derivatives, for example, N-[1-methyl-2(2-thienyl)-1-butenyl]tetracycline represented by the formula ##SPC1## The compounds have excellent antibacterial action as compared with tetracycline.

Novel N-alkenyltetracycline derivatives

Growing community of inventors

Shiraoka, Japan

Ryutaro Kawai