Kabushiki Kaisha Yakult Honsha

Mitsubishi Tanabe Pharma Corporation

Teikoku Hormone Mfg. Co., Ltd.

Nara Machinery Co., Ltd.

Ryuta Yamazaki

Shusuke Hashimoto

Takeshi Matsuzaki

Maiko Hamada

Yasuki Niwa

Ritsuo Aiyama

Kiyomi Ohba

Tatsuya Ibuki

Takashi Ikeda

Seigo Sawada

Hiroshi Hatano

Teruo Yokokura

Takashi Yaegashi

Masato Nagaoka

Tetsuji Matsudaira

Tomio Furuta

Oh Yoshida

Yukiko Nishiyama

Minoru Tanaka

Yuko Ishida

Yoshikazu Sugimoto

Hidetoshi Iwamatsu

Katsuhiko Sasako

Kwan-Hei Park

Yuichi Sawaguchi

Hideto Maruyama

Shiki Matsuki

Provided is a compound or a pharmaceutically acceptable salt thereof which is superior in an action inducing degradation of BRD4 protein and useful as a therapeutic agent for cancer. A compound represented by the following formula (I) or a pharmaceutically acceptable salt thereof: wherein each symbol is as defined in the DESCRIPTION.

Sulfonamide or sulfinamide compound having effect of inducing BRD4 protein degradation and pharmaceutical use thereof

Provided are a compound superior in a cytotoxic action on cancer cells, an action inducing degradation of BET protein in cancer cells, and an inhibitory action on the binding of BET protein and acetylated histone, and useful as an anticancer agent, a BET protein degradation inducer or a BET protein inhibitor. A compound represented by the following formula (I) wherein each symbol is as defined in the specification, or a pharmacologically acceptable salt thereof.

Amide compound having bet proteolysis-inducing action and medicinal application thereof

A method is disclosed for producing, only with mechanical treatment, high-quality rice flour having a rounded particle shape, which is equivalent to fine flour obtained by using enzymes, has characteristics close to the characteristics of wheat flour, and is suitable for production of bread, cakes, noodles, and the like. In order to attain the object, a method for producing rice flour includes: providing primary crushing material rice subjected to soaking and adjustment of moisture content with a disintegrating and sizing device, fine grinding the primary crushed rice with an air mill, and then drying the fine ground rice with an air flow dryer.

Method for producing rice flour

A novel compound having an excellent NF&#x3ba;B inhibitory effect is provided and specifically disclosed is a compound represented by the following formula (1) or a salt thereof: wherein, Rrepresents a hydrogen atom, a lower alkyl group, a lower alkyloxy group, or a halogen atom; Rrepresents a hydroxyl group, or a lower alkyloxy group; Rrepresents a hydrogen atom, a lower alkyl group, or a halogen atom; Rrepresents a hydrogen atom or a lower alkyloxy group; Rrepresents a hydrogen atom, a lower alkyloxy group, a halogen atom, a hydroxyl group, or a methylenedioxy group formed together with Ror an isopropylidenedioxy group formed together with R; Rrepresents a hydrogen atom, a lower alkyloxy group, or a methylenedioxy group formed together with Ror an isopropylidenedioxy group formed together with R; Rrepresents a hydrogen atom or a lower alkyl group; and Rrepresents a hydrogen atom, a hydroxyl group, an amino group, or a lower alkylcarbonyloxy group (excluding the case where R, R, Rand Rare hydrogen atoms, Rand Rare hydroxyl groups, and Rand Rare methoxy groups). 

Phenanthroindolizidine compound and NF&#x3ba;B inhibitor containing same as active ingredient

A breast cancer resistance protein (BCRP/ABCG2) inhibitor. The BCRP inhibitor contains, as an active ingredient, an acrylonitrile derivative or a salt thereof.

BCRP/ABCG2 inhibitor

A novel compound having an excellent NF&#x3ba;B inhibitory effect is provided. Specifically disclosed is a compound represented by the following formula (1) or a salt thereof: 

Phenanthroindolizidine derivative and NF&#x3ba;B inhibitor containing same as active ingredient

The invention provides a drug which inhibits BCRP. A breast cancer resistance protein inhibitor containing, as an active ingredient, a diphenylacrylonitrile derivative represented by the following formula (1): [wherein, each of 8 R's, which are the same or different from one another, represents a hydrogen atom, a hydroxyl group, a nitro group, an amino group, an acetylamino group (&#x2014;NHCOCHgroup); a cyano group (&#x2014;CN group); a formyl group (&#x2014;CHO group), &#x2014;COOR(Ris hydrogen or C1-C4 alkyl), &#x2014;O(CH)COOR(n=1&#x2212;7: Ris hydrogen or C1-C4 alkyl), &#x2014;OOCCHCHCOOR(Ris hydrogen, C1-C4 alkyl, (Z)-2-(3,4-dimethoxy-phenyl)-3-(4-hydroxy-phenyl)-acrylonitrile, or glycopyranosyl), a C1-C8 alkoxy group, a C1-C4 alkyl group, a halogen atom, a C1-C4 alkoxy C1-C4 alkoxy C1-C4 alkoxy group, a C2-C8 acyloxy group, a C2-C8 halogenoacyloxy group, a methylenedioxy group, a trifluoromethyl group, a phosphate group (i.e., &#x2014;OP(O) (OH)) or a salt thereof, a sulfate group (i.e., &#x2014;OSOH) or a salt thereof, a glycopyranosyl group or a salt thereof, a phosphate ester of a glycopyranosyl group or a salt of the ester, a sulfate ester of a glycopyranosyl group or a salt of the ester, or a piperidinopiperidinocarbonyloxy group], an ester thereof, or a salt thereof.

[object Object]

Specific cyclooxygenase 2 inhibitor and anti-inflammatory agent

A diarylheptanoide derivative of the following formula (1), ##STR1## and a drug composition comprising this compound, such as a 5-lipoxygenase inhibitor, an antiinflammatory agent, and the like. The diarylheptanoide derivative (1) is effective for treating and preventing various inflammatory diseases due to its strong 5-lipoxygenase inhibiting effect.

Diarylheptanoide derivative and pharmaceutical composition comprising

Growing community of inventors

Tokyo, Japan

Ryuta Yamazaki