Fujifilm Corporation

Ryuta Takegami

Yusuke Mochizuki

Kuniyuki Kaminaga

Kazuhiro Hasegawa

Naoyoshi Yamada

Kentaro Nakamura

Naohiro Matsunaga

Shigeaki Ohtani

Hiroyuki Kaihoko

Tatsuho Nomura

Katsufumi Ohmuro

Kiyokazu Hashimoto

Tadanori Yamada

Akihito Fukunaga

Makoto Fukuda

Zemin Shi

Kazuhide Kanemura

Ryo Kogawa

Toshiki Takei

Naomi Yasuda

Naomi Watanabe

Nakamura Kentaro

According to the present invention, there are provided a chamber for transplantation, as a planar chamber for transplantation which has a structure in which membranes for immunoisolation face each other, and which is capable of stably enclosing a biological constituent, including a membrane for immunoisolation at a boundary between an inside and an outside of the chamber for transplantation, in which the membranes for immunoisolation which face each other have joint portions that are joined to each other, an interior space includes a point at a distance of 10 mm or longer from any position of the joint portion, and the membrane for immunoisolation has flexibility that allows a distance of 1 mm to 13 mm as the following distance: in a case where a portion of 10 mm from a side surface of one short side of a 10 mm×30 mm rectangular test piece of the membrane for immunoisolation is vertically sandwiched between flat plates, and the flat plates are placed horizontally, a distance between a horizontal plane including a center plane in a thickness direction of the sandwiched portion of the membrane for immunoisolation, and a part, which is farthest from the horizontal plane, of a residual 20 mm-portion projecting from the flat plate; and a device for transplantation including the chamber for transplantation enclosing a biological constituent therein.

Chamber for transplantation and device for transplantation

According to the present invention, there are provided a chamber for transplantation, including a membrane for immunoisolation including a porous membrane at at least part of a boundary between an inside and an outside of the chamber for transplantation, in which the porous membrane contains a polymer and has a layered compact portion where a pore diameter is the smallest within the membrane, a pore diameter continuously increases in a thickness direction from the compact portion toward both one surface A and the other surface B of the porous membrane, a porosity in a vicinity of the surface A is 65% or more, an average pore diameter of the surface A is larger than an average pore diameter of the surface B, and the surface B is disposed on the inside of the chamber for transplantation; and a device for transplantation including the chamber for transplantation enclosing a biological constituent therein. In the chamber for transplantation of the present invention, angiogenesis in a recipient is induced and a deterioration in substance permeability is unlikely to occur.

According to the present invention, there are provided a chamber for transplantation which has a high durability, and in which an enclosed biological constituent can be maintained for a long period of time because an interior space thereof is efficiently secured; and a method for manufacturing the chamber for transplantation. The chamber for transplantation includes one or more membranes for immunoisolation at a boundary between an inside and an outside of the chamber for transplantation, in which all of the membranes for immunoisolation include a porous membrane containing a polymer, and a joint portion at which the porous membranes are directly fusion welded to each other is provided. The method for manufacturing a chamber for transplantation includes preparing one or more porous membranes containing a polymer selected from polysulfone and polyethersulfone, bringing one part of the porous membrane into direct contact with another part of the porous membrane, and performing a heat fusion welding of the two parts that are in direct contact with each other at a temperature which is a glass transition temperature of the polymer or higher and lower than a melting point of the polymer.

Chamber for transplantation, method for manufacturing chamber for transplantation, device for transplantation, and method for fusion welding porous membranes

According to the present invention, there are provided a chamber for transplantation, as a planar chamber for transplantation which has a structure in which membranes for immunoisolation face each other, and which is capable of stably enclosing a biological constituent, including a membrane for immunoisolation at a boundary between an inside and an outside of the chamber for transplantation, in which the membranes for immunoisolation which face each other have joint portions that are joined to each other, an interior space includes a point at a distance of 10 mm or longer from any position of the joint portion, and the membrane for immunoisolation has flexibility that allows a distance of 1 mm to 13 mm as the following distance: in a case where a portion of 10 mm from a side surface of one short side of a 10 mm&#xd7;30 mm rectangular test piece of the membrane for immunoisolation is vertically sandwiched between flat plates, and the flat plates are placed horizontally, a distance between a horizontal plane including a center plane in a thickness direction of the sandwiched portion of the membrane for immunoisolation, and a part, which is farthest from the horizontal plane, of a residual 20 mm-portion projecting from the flat plate; and a device for transplantation including the chamber for transplantation enclosing a biological constituent therein.

An object of the present invention is to provide a separation substrate having a high megakaryocyte blocking rate and a high platelet permeation rate, and a cell separation filter and a method for producing a platelet which use the same. The separation substrate of the present invention is a separation substrate including non-woven fabric for separating a platelet from a cell suspension containing a megakaryocyte and the platelet, in which an average pore diameter of the separation substrate is 2.0 &#x3bc;m to 15.0 &#x3bc;m, and a thickness of the separation substrate is 10 &#x3bc;m to 500 &#x3bc;m.

Separation substrate, cell separation filter, and method for producing platelet

An object of the present invention is to provide a cell transplant device having an ability to induce angiogenesis around the cell transplant device, and a method for manufacturing the same. According to the present invention, a cell transplant device including a cell structure (A) that includes a plurality of biocompatible polymer blocks and a plurality of cells of at least one type, and in which at least one of the biocompatible polymer blocks is disposed in gaps between the plurality of cells; and an immunoisolation membrane (B) that encloses the cell structure is provided.

Cell transplant device and method of manufacturing the same

According to the present invention, there are provided a membrane for immunoisolation, including: a porous membrane that contains a polymer, in which the porous membrane includes a layered compact portion where a pore diameter is the smallest within the membrane, and a pore diameter continuously increases in a thickness direction from the compact portion toward at least one surface of the porous membrane; a chamber for transplantation for enclosing a biological constituent therein, including the above-described membrane for immunoisolation on at least a part of a surface forming an inside and an outside of the chamber for transplantation; and a device for transplantation, including the above-described chamber for transplantation enclosing the biological constituent therein. In the membrane for immunoisolation of the present invention which can be manufactured at low costs, a deterioration in substance permeability is unlikely to occur.

Membrane for immunoisolation, chamber for transplantation, and device for transplantation

According to the present invention, there is provided a membrane for immunoisolation, including a porous membrane that contains a polymer, in which Formulas (I) and (II) are satisfied for at least one surface of the porous membrane, B/A&#x2264;0.7 (I) and A&#x2265;0.015 (II) (in the formula, A represents a ratio of an N element to a C element on a surface of the membrane, and B represents a ratio of the N element to the C element at a depth of 30 nm from the surface of the membrane); a chamber for transplantation for enclosing a biological constituent therein, including the above-described membrane for immunoisolation on at least a part of a surface forming an inside and an outside of the chamber for transplantation; and a device for transplantation includes the above-described chamber for transplantation enclosing the above-described biological constituent therein. The membrane for immunoisolation of the present invention has a high bioaffinity.

An optical film in which heat resistance or moisture resistance is excellent, and visibility is able to be sufficiently ensured. In the optical film used in a display apparatus including a polarizer, Re is 1,000 nm to 30,000 nm, and Rth is &#x2212;30,000 nm to &#x2212;1,000 nm. Further, a polarization plate including the optical film, a transparent conductive film including the optical film, a surface protection film including the optical film including the optical film, and a liquid crystal display apparatus including the optical film.

Optical film, polarization plate, transparent conductive film, surface protection film, and liquid crystal display apparatus having negative birefringence

A film includes a substrate including a cyclic olefin-based resin; and an easily adhesive layer adjacent to the substrate, in which a content of a fluorine-containing polymer in the easily adhesive layer is greater than 20 mass % with respect to a total mass of the easily adhesive layer. This film is used in a transparent conductive film, and this transparent conductive film is used in a touch panel. A method for producing a film includes laminating an easily adhesive layer by directly applying a coating liquid for forming an easily adhesive layer on a substrate including a cyclic olefin-based resin, in which a content of a fluorine-containing polymer in the coating liquid for forming the easily adhesive layer is greater than 20 mass % with respect to a total mass of the coating liquid for forming the easily adhesive layer.

Film, method for producing same, transparent conductive film, and touch panel

An image display device including a polarizer and a first optical film, in which the first optical film is arranged on a visible side from the polarizer, the first optical film has Re(589) of 3,000 nm to 30,000 nm and Rth(589) of &#x2212;30,000 nm to &#x2212;3,000 nm, an angle &#x3b8;between a slow axis of the first optical film and an absorption axis of the polarizer is 45&#xb0;&#xb1;30&#xb0;, and the image display device is a liquid crystal display device including a blue or ultraviolet LED, a fluorescent body, and a liquid crystal cell, or an organic EL display device, is able to suppress the occurrence of rainbow unevenness without darkening brightness at the time of being observed by mounting polarized sunglasses, and is able to suppress the occurrence of the rainbow unevenness without darkening the brightness at the time of being observed by mounting the polarized sunglasses even in a case where a film which has great optical anisotropy and is stretched in at least a monoaxial direction is further provided on the visible side of the image display device.

Image display device

A back protective sheet for a solar cell module containing a polyester support that is biaxially stretched and then subjected to a thermal fixation treatment; and a polymer layer arranged to be in contact with at least one surface of the polyester support, wherein the polymer layer contains a binder having at least one functional group selected from a carboxyl group, a hydroxyl group, an amino group, a sulfonic acid group, and a carbonyl group; a pigment; and a crosslinking agent-derived structure, and the polyester support contains a polyester, a pigment, and an terminal blocking agent, has excellent adhesion between the support and the functional layer after wet heat aging.

Back protective sheet for solar cell module and solar cell module

A polyester resin composition including: a polyester resin; a titanium compound derived from a catalyst; and a phosphorous compound, wherein formula (1): 0.10&#x3c;Ti/P&#x3c;0.20 is satisfied wherein Ti/P represents a mass content ratio of titanium element to phosphorus element in the polyester resin composition, and formula (2): 0.0090&#x3c;&#x394;IV&#x2266;0.0185 (dL/g/hr) is satisfied wherein &#x394;IV represents an increase in an intrinsic viscosity of the polyester resin composition per hour under conditions of 225&#xb0; C. and 50 Pa.

Method of producing a polyester resin composition

The invention relates to an optical compensation film for IPS or FFS-mode liquid crystal display devices, having the tilt angle &#x3b2;[&#xb0;] not equal to zero, &#x3b2;[&#xb0;] being defined as &#x3c6; giving the minimum value of retardation R[&#x3c6;] which is retardation measured for incident light coming in a direction tilted by &#x3c6;&#xb0; from a normal line relative to the film-plane, the direction being in a plane including the direction perpendicular to the in-plane slow axis thereof and the normal line; and having retardation along the thickness direction at a wavelength of 550 nm, Rth(550), not equal to zero.

Growing community of inventors

Kanagawa, Japan

Ryuta Takegami