Dojindo Laboratories

Ryusuke Tsunoda

Hiroshi Maeda

Takaaki Akaike

Kazumi Sasamoto

Ken Okumura

Keizo Sato

Yoshiki Katayama

This invention offers the compounds which exhibit a coronary blood vessel dilating action which is long-acting. (Constitution) Novel imidazolinoxyl derivatives represented by a general formula (1). A compound A in which R is COOH is given in an example. ##STR1## (Merit) The compounds of the present invention can be directly administered, after diluting to a suitable concentration with a phosphate buffer or the like, to blood vessel which is required to be relaxed and dilated whereby a significant and long-acting relaxing action is resulted though, in a blood flow, they are quickly inactivated and excreted and no side effect is noted.

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Kumamoto, Japan

Ryusuke Tsunoda