Ajinomoto Co., Ltd.

Ryusuke Hirama

Toshihiro Hatanaka

Seiji Niwa

Nobuo Kondo

Takao Ikenoue

Akiyo Yamazaki

Yoko Masuzawa

Hideyuki Tanaka

Hiroyuki Matsueda

Takashi Yamamoto

Yukio Iino

Masaru Takayanagi

Wataru Miyanaga

Fumio Ohta

Koji Ohsumi

Yoko Kageyama

Katsumi Maezono

Itsuya Tanabe

Nozomu Ishida

Tatsuya Ishikawa

Yoriko Okamatsu

The present invention provides a fused polycyclic compound of the following formula, analogues thereof and pharmaceutically acceptable salts thereof; and agents for increasing the sugar-transporting capacity, hypoglycemic agents and pharmaceutical compositions containing the above compounds. This fused polycyclic compound has high medicinal properties and few side-effects, and a therapeutic effect on diabetes. wherein R represents an alkoxy group, R' represents an oxazolylpropionyl group or a thiazolylpropionyl group, and R&#x2033; represent a hydrogen atom.

Fused polycyclic compounds having a heterocyclic ring(s) and pharmaceutical use thereof

The invention provides a prophylactic and therapeutic agent of diabetes mellitus, including a combination of an inhibitor of renal glucose reabsorption and a hypoglycemic agent. In accordance with the invention, hyperglycemia after meals, between meals and during fasting can be ameliorated. More specifically, in accordance with the invention, a therapeutic effect of diabetes mellitus as never been obtained by the hypoglycemic agents of the related art can be achieved.

Prophylactic and therapeutic agent of diabetes mellitus

The present invention provides a lactam compound, a sugar transport enhancement agent containing this compound as an active ingredient, an agent for the prevention and/or treatment of diabetes mellitus, diabetic peripheral neuropathy, diabetic nephropathy, diabetic retinopathy, diabetic macrovascular disease, glucose tolerance anomaly, obesity and the like. In addition, the present invention also provides a preparation method for the novel lactam compound, and a preparation intermediate thereof.

Lactam compound, a method for producing the same, and a diabetic therapy by administering the same

The following fused polycyclic compound, analogues thereof or pharmaceutically acceptable salts thereof have an effect of increasing the sugar-transporting capacity and an effect of lowering the blood glucose level and, therefore, they are useful for preventing and/or treating diabetes and the like. wherein R is a methoxy group, Y is a (2-thiazolyl)-2-ethylcarbonyl group, Rand Rare hydrogen atoms, and Rand Rare methyl groups.

Fused polycyclic compounds

An agent for increasing the sugar-transporting capacity and an agent for preventing and/or treating diabetes, diabetic peripheral neuropathy, diabetic nephropathy, diabetic retinopathy, diabetic macroangiopathy, impaired glucose tolerance or adiposis, which contains a lactam compound or a pharmaceutically acceptable salt thereof as the active ingredient.

Lactam compounds and pharmaceutical use thereof

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Kawasaki, Japan

Ryusuke Hirama