Institute of Medicinal Molecular Design, Inc.

Ryukou Tokuyama

Akiko Itai

Susumu Muto

Tatsurou Ichige

Toshifumi Wakamatsu

A compound represented by the following formula (I) or a salt thereof: wherein R, R, Rand Rrepresent hydrogen atom, a halogen atom, cyano group, nitro group, a Calkyl group, a halogenated Calkyl group or a Calkoxy group, Rrepresents a halogen atom, cyano group, a Calkyl group, a halogenated Calkyl group or a Calkoxy group, Rrepresents a Ccycloalkyl group, a substituted Ccycloalkyl group, a 5 to 7-membered completely saturated heterocyclic group or a substituted 5 to 7-membered completely saturated heterocyclic group, X represents a single bond, oxygen atom, sulfur atom, NR, &#x2014;O&#x2014;CH&#x2014; or &#x2014;N(R)&#x2014;CH&#x2014;, Rrepresents hydrogen atom or a Calkyl group, or Rmay combine with a substituent of Rto represent a single bond, methylene group or ethylene group, Rrepresents hydrogen atom, a Calkyl group or a Caralkyl group, which is useful as an active ingredient of a medicament for prophylactic and/or therapeutic treatment of diseases caused by an activation of STAT6 and/or NF-&#x3ba;B.

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Tokyo, Japan

Ryukou Tokuyama