Shionogi Company Limited

Matsushita Electric Industrial Co., Ltd.

Ryuji Suzuki

Mitsuaki Ohtani

Akinori Arimura

Kenji Kawada

Shigeki Ueda

Teruhisa Takano

Kohji Hanasaki

Saichi Matsumoto

Tsuneaki Sakata

Hirokuni Jyoyama

Toshiyuki Kamigauchi

Kenzo Koizumi

Shinji Kakudo

Kimiaki Yamaguchi

Haruo Matsushima

Shunichi Nagamoto

Takashi Niwa

Tomoko Maeda

Takahiro Ochi

The present invention provides a selective suppressor of the IgE production comprising a compound which suppresses the IgE production in a process from a differentiation of a mature B cell into an antibody-producing cell to the production of an antibody and which does not suppress or weakly suppresses the production of IgG, IgM and/or IgA which are produced at the same time, a compound of the formula (I): wherein R&#x2013;Rare hydrogen, halogen, lower alkyl, lower alkoxy or the like, X is &#x2014;O&#x2014;, &#x2014;CH&#x2014;, &#x2014;NR&#x2014; or &#x2014;S(O)p- and Y is lower alkyl, lower alkenyl or the like, a process for producing the same and a pharmaceutical composition comprising the same.

Para-terphenyl compounds

The present invention provides a selective suppressor of the IgE production comprising a compound which suppresses the IgE production in a process from a differentiation of a mature B cell into an antibody-producing cell to the production of an antibody and which does not suppress or weakly suppresses the production of IgG, IgM and/or IgA which are produced at the same time, a compound of the formula (I): wherein R&#x2013;Rare hydrogen, halogen, lower alkyl, lower alkoxy or the like, X is &#x2014;O&#x2014;, CH&#x2014;, &#x2014;NR&#x2014; or &#x2014;S(O)&#x2014; and Y is lower alkyl, lower alkenyl or the like, a process for producing the same and a pharmaceutical composition comprising the same.

P-terphenyl compounds

The present invention provides a selective suppressor of the IgE production comprising a compound which suppresses the IgE production in a process from a differentiation of a mature B cell into an antibody-producing cell to the production of an antibody and which does not suppress or weakly suppresses the production of IgG, IgM and/or IgA which are produced at the same time, a compound of the formula (I): wherein R&#x2013;Rare hydrogen, halogen, lower alkyl, lower alkoxy or the like, X is &#x2014;O&#x2014;, &#x2014;CH&#x2014;, NR&#x2014; or &#x2014;S(O)p&#x2014; and Y is lower alkyl, lower alkenyl or the like, a process for producing the same and a pharmaceutical composition comprising the same.

This invention relates to: a method for differentiating osteoclast precursor cells (preosteoclasts) into osteoclasts, which comprises culturing the preosteoclasts in the absence of accessory cells; a method for isolating preosteoclasts, which comprises culturing peripheral blood or joint fluid in the absence of cytokine for 1 to 3 weeks; an preosteoclasts, which is obtainable by the above method; a method for differentiating the preosteoclasts obtained by the above method into osteoclasts, which comprises culturing the preosteoclasts in the absence of accessory cell; an osteoclast, which is obtainable by the above method; a method for screening agents for treating metabolic bone diseases, which comprises using the preosteoclasts or the osteoclasts as described above; and agents for treating metabolic bone diseases, which is obtainable by the above screening method.

Methods for isolation of osteoclast precursor cells and inducing their differentiation into osteoclasts

Antirheumatic agent

Antirheumatic

The present invention is a microorganism which is,RF-5762 (FERM BP-5882), wherein said microorganism is capable of producing a compound of the following formula (I):

Microorganism producing terphenyl compounds

Terphenyl compounds and medicines containing the same

A heating apparatus, such as an electric oven or a microwave oven, comprises an enclosure case having therein a heating chamber to place a heating object therein, the enclosure case having a door at an opening of the chamber, and the door having a locking means, to lock the door when closed, and has a door lock releasing means, such as a lever and a solenoid planger, to release and open the door from the locking state of the locking means,

Heating apparatus with voice actuated door opening mechanism

A turntable drive mechanism for a microwave oven having an oven-defining structure having a bottom wall and a hingedly supported door for selectively closing and opening an access opening leading into the interior of the oven-defining structure. The turntable drive mechanism has a turntable assembly removably positioned on the bottom wall for rotation about its own center through a plurality of rollers situated between the turntable assembly and the bottom wall, and a plurality of magnets. Cooperating with these magnets carried by the turntable assembly are magnets carried by a rotary carriage driven by a drive unit in one direction and situated below the bottom wall and externally of the oven-defining structure. Rotation of the turntable assembly is induced by rotation of the rotary carriage by the effect of magnetic forces of attraction developed through the bottom wall between the magnets on the turntable assembly and the magnets on the rotary carriage.

Turntable drive mechanism in electronic oven

Growing community of inventors

Nara, Japan

Ryuji Suzuki