Kao Corporation

Ryuji Ochiai

Atsushi Suzuki

Ichiro Tokimitsu

Jun Kohori

Shigemi Tsuchiya

Akihiko Fujii

Yusuke Shibuya

Hideo Oominami

Yoko Seo

Hiroyuki Nakayama

Shin Koike

Kazuyuki Yahagi

Koichi Okisaka

Kouzi Morita

Youko Seo

Noboru Shirahata

Yoshie Yamasaki

Provided is a coffee composition which does not generate hydrogen peroxide in the body even if it is taken for long periods of time. The coffee composition has a hydroxyhydroquinone content of 0 to 0.00005 wt. %.

Coffee drink composition

Provided is a coffee composition having an excellent hypotensive effect. The coffee composition has the following components (A) and (B):

The present invention is a liquid seasoning containing the following (A), (B), and (C):

Liquid seasoning

Provided is a method of treating hypertension, which comprises administering an effective amount of a compound represented by the following formula (1) or (2): wherein, Rand Rare the same or different and each independently represents hydrogen, alkyl, alkenyl, cycloalkyl, cycloalkenyl, alkoxyalkyl, aryl, alkylaryl, aralkyl, or acyl, Rrepresents hydroxyl, ester bond residue, or amide bond residue, Rrepresents ester bond residue or amide bond residue, or a pharmaceutically acceptable salt thereof (except ferulic acid). When the preventive or remedy for hypertension according to the present invention is administered, ferulic acid exists in the blood for a long period of time, thereby continuously suppressing a blood pressure rise. Moreover, the hypertension preventive or remedy according to the present invention has reduced in bitterness peculiar to ferulic acid, which enables patients to take it continuously.

Remedy for hypertension

Products and compositions for preventing or reducing the severity of hypertension. These products contain (a) ferulic acid or a ferulate ester, and (b) caffeic acid and/or a chlorogenic acid. The preventive or remedy can suppress a rise in blood pressure and alleviate hypertension, and is usable as a food.

Compositions and methods for alleviating hypertension or preventing a rise in blood pressure

The present invention provides a liquid seasoning, which brings on a sufficient salty taste although it has a low sodium concentration, and which exhibits for example a pharmacological effect such as an antihypertensive effect at a high level. The present invention relates to a liquid seasoning, which contains the following components (A) to (D):

Low sodium liquid seasoning with anti-hypertensive activity

Provided is a method of treating hypertension, which comprises administering an effective amount of a compound represented by the following formula (1) or (2): wherein, Rand Rare the same or different and each independently represents hydrogen, alkyl, alkenyl, cycloalkyl, cycloalkenyl, alkoxyalkyl, aryl, alkylaryl, aralkyl, or acyl, Rrepresents hydroxyl, ester bond residue, or amide bond residue, Rrepresents ester bond residue or amide bond residue, or a pharmaceutically acceptable salt thereof (except ferulic acid).

Preventive or remedy for hypertension

The invention relates to an agent for preventing, improving or treating hypertension, which exhibits a hypotensive effect, inhibits the rise of blood pressure and improves hypertension, and food for preventing or improving hypertension, which does not become a burden in daily intake, has a higher antihypertensive effect and is useful as a diet during treatment for patients of hypertension. The agent for preventing, improving or treating hypertension contains the following components (A) and (B):

Agent for preventing, improving or treating hypertension

Provided is a mineral absorption enhancing method comprising administering an effective amount of a green coffee bean extract. The present invention can relieve mineral deficiency by using a mineral absorption enhancer which is excellent in safety and has an excellent mineral absorption enhancing effect.

Mineral absorption enhancer

Provided is a method of treating hypertension, which comprises administering an effective amount of a compound represented by the following formula (1) or (2):wherein, Rand Rare the same or different and each independently represents hydrogen, alkyl, alkenyl, cycloalkyl, cycloalkenyl, alkoxyalkyl, aryl, alkylaryl, aralkyl, or acyl, Rrepresents hydroxyl, ester bond residue, or amide bond residue, Rrepresents ester bond residue or amide bond residue, or a pharmaceutically acceptable salt thereof (except ferulic acid). When the preventive or remedy for hypertension according to the present invention is administered, ferulic acid exists in the blood for a long period of time, thereby continuously suppressing a blood pressure rise. Moreover, the hypertension preventive or remedy according to the present invention has reduced in bitterness peculiar to ferulic acid, which enables patients to take it continuously.

A method for treating hypertension, a cardiac disease, or a cerebrovascular disease comprising administration of ferulic acid or a derivative thereof, to a subject in need of treatment. Therapeutic compositions comprising ferulic acid and its derivatives may comprise pharmaceutical products, nutritional supplements or products, and foods. Such compositions may further comprising diglycerides in combination with ferulic acid and its derivatives.

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Haga-gun, Japan

Ryuji Ochiai