Hitachi, Ltd.

Kabushiki Kaisha Yakult Honsha

Ryuichiro Tanaka

Toru Kiyota

Hiroyuki Kogane

Takao Aoki

Masahiko Mutai

Tsukasa Ariyoshi

Akemi Takahashi

Taisuke Kashima

Shigeki Gushiken

Toshizo Sakurai

Koutaro Takamizawa

Hiroo Takayama

Yasushi Fujitani

Koichi Watanabe

Keisuke Matsumoto

Kenta Kumagai

Eiji Yamamoto

Yoshitaka Nagai

Kazuyuki Tsuburaya

Mitsuo Mada

Noritaka Segawa

Junji Fujimoto

Tsuneo Terashima

Kouichi Kasama

Toru Higashihara

Mitsuo Kawaguchi

Takahiro Matsuki

Masami Morotomi

Tomokatsu Saitou

Takaharu Yamamoto

Yukiko Miyamoto

Tokutaro Takahashi

Akio Kuroda

Sadao Ueyama

Tsuyoshi Osanai

Katsuhiro Tomaru

The present invention provides an apparatus for extracting nucleic acid from a specimen, including traditionally difficult specimens, in preparation for polymerase chain reaction (PCR) analysis. The apparatus includes: a shaker, a centrifugal separator, a particle supply mechanism for supplying particles of different sizes, a liquid chemical supply mechanism, a conveyance arm for transporting the specimen or tube-containing specimen, and a control means. The control means is designed to shake tubes containing large and small diameter particles and transport the tubes through a centrifuge in order to separate the nucleic acid-containing material from the remainder of the specimen and crush the material to extract the nucleic acid.

Nucleic acid extraction device

Oligonucleotides which specifically hybridize to rRNAs of Bifidobacterium infantis, Bifidobacterium bifidum, Bifidobacterium adolescentis, Bifidobacterium breve, and Bifidobacterium longum represented by the sequences of formulae (I) to (V), respectively, or sequences complementary thereto:

Species-specific oligonucleotides for bifidobacteria and a method of

A botulinum toxin neutralizer comprising at least one fatty acid having the number of carbon atoms of at least 12. Such a fatty acid may be any of saturated fatty acids such as lauric acid, myristic acid, palmitic acid, stearic acid, nonadecanoic acid, arachidic acid, and behenic acid or any of unsaturated fatty acids such as oleic acid. The toxin neutralizer acts as if it were an antagonistic receptor for botulinum toxin and, when encountering botulinum toxin in human body, directly combines with the toxin and disables the toxin from combining with the neuromuscular tissues of human body to prevent the outbreak of botulism. The toxin thus neutralized and affixed to the botulinum toxin neutralizer is excreted from the human body. The botulinum toxin neutralizer can be manufactured easily and economically from a naturally occurring glyceride and is thus far less costly then the known antitoxin of ganglioside GT1b produced from bovine brain.

Botulinum toxin neutralizer

Projecting television receiver

Television receiver

A botulinus toxin neutralizer comprising heat-treated fat globule membranes of animal milk or gangliosides isolated from fat globule membranes of animal milk. The neutralizer of the former nature is prepared from a material containing fat globules of animal milk by fractionating the material for separating the membranes of the fat globules from the rest of the material, and subjecting the separated fat globule membranes to heat treatment. The neutralizer of the former nature is prepared from a material containing fat globules by fractionating the material for separating the membranes of the fat globules from the rest of the material, and isolating gangliosides from the globule membranes.

Botulinus toxin neutralizer

This invention relates to a composition for promoting growth of Bifidobacteria containing as effective constituent an oligosaccharide represented by the general formula Gal-(gal).sub.n -Glc, wherein Gal denotes a galactose residue, Glc a glucose residue and n an integer of 1 to 4. This invention further relates to a method for manufacture of the material for promoting growth of Bifidobacteria characterized in that lactose or a lactose-containing material is treated with .beta.-galactosidase produced by Aspergillus oryzae.

Composition for promoting growth of bifidobacteria

Growing community of inventors

Kokubunji, Japan

Ryuichiro Tanaka