Other

Shin-etsu Chemical Co., Ltd.

Ryuichi Sato

Akira Ishikawa

Yukihito Ishida

Shiro Ikegami

Hiroshi Satoh

Shigeshi Toyoshima

Setsuo Tomisawa

Shigeru Toyoshima

Toshio Shinohara

Yasushi Yamamoto

Shoji Ichinohe

Masatoshi Arai

Koichi Ito

Hiroshi Sato

Setuso Tomisawa

The invention provides a novel compound 2-(3-trimethylsilylpropyl)benzothiazole having remarkable anti-tumor effects or, in particular, inhibiting growth of melanoma cells in test animals. The compound is synthesized by the ring-closing intramolecular dehydration condensation of 2-mercapto-(.gamma.-trimethylsilyl)butyroanilide which in turn is obtained by the dehydrochlorination condensation of 2-aminothiophenol and .gamma.-trimethylsilylbutyryl chloride in a polar solvent in the presence of an acid acceptor.

2-(3-Trimethylsilylpropyl)benzothiazole

A novel medicament which is effective as an antihypertensive agent is proposed which contains, as its effective ingredient, an organosilicon compound represented by the general formula

Medicaments containing an organosilicon compound

The invention provides a novel anti-tumor agent highly effective for inhibiting growth of several tumor or cancer cells with low toxicity. The active ingredient contained in the anti-tumor agent is an .omega.-triorganosilyl-substituted linear alkanoic acid anilide which is a hitherto unknown novel compound prepared by the reaction of corresponding acid chloride and aniline.

Novel organosilicon compounds and anti-tumor agents containing the same

Germanium-containing organic polymers are obtained by polymerizing 3-trichlorogermylpropionic acid obtained by reacting halogermanium-phosphoric acid complexes with acrylic acid. The polymers are markedly effective in treating allergenicities.

Germanium-containing organic polymer and its use in the treatment of

Germanium-containing organic polymers are obtained by polymerizing 3-trichlorogermylpropionic acid obtained by reacting halogermanium-phosphoric acid complexes with acrylic acid. The polymers are markedly effective in treating pulmonary fibrosis.

Germanium-containing organic polymers are obtained by polymerizing 3-trichlorogermylpropionic acid obtained by reacting halogermanium-phosphoric acid complexes with acrylic acid. The polymers are markedly effective in treating liver disorders.

Germanium-containing organic polymers are obtained by polymerizing 3-trichlorogermylpropionic acid obtained by reacting halogermanium-phosphoric acid complexes with acrylic acid. The polymers are markedly effective in treating opthalmological disorders.

Germanium-containing organic polymers are obtained by polymerizing 3-trichlorogermylpropionic acid obtained by reacting halogermanium-phosphoric acid complexes with acrylic acid. The polymers are markedly effective in treating psychoneurological disorders.

Germanium-containing organic polymer and it's use in the treatment of

The invention provides a novel class of organosilicon compounds and a method for the preparation thereof as well as an anti-tumor agent containing the compound having very remarkable anti-tumor activity but with very low toxicity. The inventive compound is a (trihydrocarbylsilylmethyloxyimino)alkane, which is a silicon-containing oxime compound hitherto not described in any prior art literatures, represented by the general formula R.sup.1.sub.3 Si--CH.sub.2 --O--N.dbd.Y, R.sup.1 is a substituted or unsubstituted monovalent hydrocarbon group having from 1 to 10 carbon atoms and Y is a divalent hydrocarbon group denoted by .dbd.CR.sup.2 R.sup.3 or .dbd.CR.sup.4, R.sup.2 and R.sup.3, which may be identical or different, having the same meaning as R.sup.1 defined above and R.sup.4 being an alkylene group to form a ring structure jointly with the carbon atom directly bonded to the nitrogen atom. Typical examples of the compounds are: 2-(trimethylsilylmethyloxyimino) butane, 2-(trimethylsilylmethyloxyimino)propane, 2-(dimethylphenylsilylmethyloxyimino) butane and trimethylsilylmethyloxyiminocyclohexane.

Novel organosilicon compounds and anti-transplanted tumor agents

Germanium-containing organic polymers are obtained by polymerizing 3-trichlorogermylpropionic acid obtained by reacting halogermanium-phosphoric acid complexes with acrylic acid. The polymers are markedly effective in mental diseases, disturbances in heart and vascular systems and are also effective against various cancers.

Germanium-containing organic polymer and the process for the production

The present invention presents a novel class of compounds bis(triorganosilylalkyl) phosphites, e.g. bis(trimethylsilylmethyl) phosphite. The compound is readily prepared by the reaction of a corresponding triorganosilyl alkanol with phosphorus trichloride or by the partial hydrolysis of a corresponding tris(triorganosilylalkyl) phosphite with an equimolar amount of water followed by distillation of the reaction mixture. The compound has a remarkable anti-transplanted tumor effectiveness as established by the test with mice as the test animals for preventing the growth of Ehrlich's cancer cells and Sarcoma 180 cells. The compound has very low toxicity when orally administrated.

Bis(triorganosilylalkyl) phosphites

Novel pharmacologically important organic germanium compounds (3-hydroxygermyl propionic acid salts) represented by the formula ##STR1## WHEREIN Met is a monovalent cation selected from the group consisting of Na, K, NH.sub.4, and NH.sub.2 (CH.sub.3).sub.2, or divalent cation selected from the group consisting of Ca and Mg, and wherein x is 1 when Met is a monovalent cation and x is 2 when Met is a divalent cation. These compounds possess valuable therapeutic properties for treating such physiological abnormalities as psychiatric and neurological disorders, metabolic disorder, cardivascular disorder, disorder of digestive organs, skin disease, allergic disease, Kidney dysfunction, hepatic dysfunction, obstetric and pediatric diseases, etc., and the process for preparing thereof.

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Gunma, Japan

Ryuichi Sato