The Chemo-sero-therapeutic Research Institute

Km Biologics Co., Ltd.

Ryuichi Sakamoto

Masashi Sakaguchi

Hiroshi Mizokami

Takeshi Arakawa

Toshihiro Ushijima

Takeshi Miyata

Hirotaka Uefuji

Tetsuya Harakuni

Kenichi Yamazaki

Kiyohiko Andoh

Kiyotaka Suenaga

Susumu Baba

Takashi Imamura

A vaccine composition for birds comprising as an active ingredient a structure containing O-antigen derived from Gram-negative bacteria, provided that said structure does not contain a whole cell, and a process for preparing the same are provided. By using a structure containing O-antigen (e.g. lipopolysaccharide) derived from Gram-negative bacteria as an active ingredient in accordance with the present invention, alleviation of inoculation reaction and reduction in an amount of injection are attained as compared to the conventional whole-cells vaccine to thereby allow for the increase in the number of other antigens to be mixed therewith.

LPS vaccine

The present invention is intended to provide an egg drop syndrome (EDS) vaccine that is capable of effectively preventing EDS and can be stably supplied. The EDS vaccine provided to this end contains as an active ingredient fused protein in which a polypeptide having a coiled-coil forming unit is bound to the knob region in the fiber protein of EDS virus (EDSV).

Prophylactic vaccine against egg drop syndrome (EDS)

A recombinant avian infectious coryza vaccine and a process for preparing the same are provided. A process for preparing a recombinant avian infectious coryza vaccine which comprises step of constructingthat may produce as an inclusion body a fusion peptide consisting of peptides derived from outer-membrane protein ofserotype A and serotype C, step of culturing saidand collecting and purifying inclusion body from culture, and step of preparing a preparation comprising said purified inclusion body, and an avian infectious coryza vaccine comprising as an active ingredient the fusion peptide. A linker sequence may be inserted between the respective peptides comprising the fusion peptide. For the peptide derived from the serotypes A and C, an amino acid sequence region of Region 2 or its vicinity responsible for protection from infection may be used.

Recombinant avian infectious coryza vaccine and process for preparing same

A method and a kit for detecting an antibody toare provided. A method for detecting an antibody towhich comprises detecting an antibody induced by an outer-membrane protein ofserotype A and/or serotype C by ELISA with a solid phase to which a peptide consisting of an amino acid sequence of non-homologous region of said outer-membrane protein or a portion thereof is immobilized, and a detection kit used for said method.

Method and kit for detecting antibody to avibacterium paragallinarum

Growing community of inventors

Kumamoto, Japan

Ryuichi Sakamoto