Ss Pharmaceutical Co., Ltd.

Ryuichi Kawahara

Hideaki Matsuda

Takemitsu Asaoka

Naokata Taido

Tadayuki Kuraishi

Akihiro Shibata

Masaru Matsumoto

Sunao Takeda

Fujiko Konno

Tatsuhiko Katori

Minoru Tokizawa

Kazunori Maebashi

Yoshihiko Kanamaru

Tasdayuki Kuraishi

A quinolone carboxylic acid derivative having the following formula (1), ##STR1## wherein R.sup.1 is a hydrogen atom, an alkyl group, an aralkyl group, an ester residual group which can be hydrolyzed in living bodies, R.sup.2 is a hydrogen atom or an amino group which may be substituted by one or two lower alkyl groups, X is a hydrogen atom or a halogen atom, Y is CH.sub.2, O, S, SO, SO.sub.2, or N--R.sup.3, wherein R.sup.3 is a hydrogen atom or a lower alkyl group, and Z is an oxygen atom or two hydrogen atoms; or a salt thereof; and an antimicrobial agent comprising the same. The compound exhibits a superior antimicrobial activity, especially against gram positive microorganisms, and is thus useful for the treatments and prevention of various infectious diseases in clinics.

Quinolone carboxylic acid derivatives

Quinoline carboxylic acid derivatives

A triazole derivative is disclosed. The compound have a general formula, ##STR1## wherein R.sup.1 and R.sup.2 represent a hydrogen atom or a lower alkyl group, or R.sup.1 and R.sup.2 together form a lower alkylene group, R.sup.3 represents a lower alkyl group, and n denotes an integer of 0 to 2, provided that not both R.sup.1 and R.sup.2 are a hydrogen atom at the same time. The triazole derivatives and their salts are effective for curing or preventing deep-seated mycoses, e.g. mycotic meningitis, mycotic infectious diseases of respiratory organs, fungemia, and urinary tract mycosis.

Triazole derivatives and a composition for treating mycoses

Growing community of inventors

Ichikawa, Japan

Ryuichi Kawahara