Astellas Pharma Gmbh

Sirim Berhad

Tropbio Research Sdn.bhd

Ryuichi Kanasaki

Koji Yoshikawa

Ikuko Nakamura

Shigehiro Takase

Keisuke Ohsumi

Teruhisa Masaki

Neelam Shahab

A compound useful as an antifungal agent, particularly a therapeutic agent for deep-seated mycoses, is provided. A funguswas collected, and cyclic compounds were isolated from culture liquids thereof. The present inventors confirmed that the cyclic compounds or salts thereof have a potent antifungal activity and are useful as medicaments, particularly an antifungal agent, and thus the present invention was completed. The cyclic compound and the salt thereof according to the present invention can be used as an agent for preventing or treating mycoses, particularly deep-seated mycoses.

Cyclic compound and salt thereof

A microorganism which produces compounds useful as an antifungal agent, particularly a therapeutic agent for deep-seated mycoses, such as mycotic sinusitis, is provided. The present inventors have conducted intensive studies on naturally-occurring microorganisms as a research for antifungal compounds, and found a funguswhich produces cyclic compounds having a potent antifungal activity and useful as a medicament, particularly an antifungal agent, and the present invention was completed.

Microorganism producing cyclic compound

Growing community of inventors

Tokyo, Japan

Ryuichi Kanasaki